Features | Partner Sites | Information | LinkXpress
Sign In
SEEGENE
FOCUS DIAGNOSTICS, INC.
RANDOX LABORATORIES

Genetic Key Found for Cancer Patient's Treatment Failure

By Labmedica International staff writers
Posted on 26 Jan 2012
A gene variation has been found which can have a substantial effect on treatment responses in patients with a rare type of blood cancer.

The cluster of differentiation 95 (CD95) gene is one of the genes involved in controlling the death of cells in the body and having an abnormal version of the CD95 gene could also dictate survival rates for other cancer types like lymphoma, breast, and prostate cancer.

Scientists at Newcastle University (Newcastle upon Tyne, UK) used various molecular techniques to investigate the DNA and RNA of 654 patients enrolled in a leukemia trial. This included data from 231 people diagnosed with acute promyelocytic leukemia (APL).

The study revealed that patients with an abnormal variant of the CD95 gene have a substantially lower chance of survival, with just 64% of APL study participants with the variant surviving long-term, compared with 79% who have a normal version of the gene. Patients with the gene variant often failed to respond to treatment from the start and died from infection within weeks of diagnosis. Leukemia patients who fail to respond to chemotherapy are often susceptible to infections. It is difficult to predict which patients are at high risk of developing this life-threatening complication, and the scientists discovered that APL patients with the risk gene had a five times higher likelihood of dying from infection compared with patients with the more common version of the gene.

Molecular methods included in the study were the caspase-8 and caspase-3 cleavage assay using ligands from Enzo Life Sciences, (Farmingdale, NY, USA) and the Dual Luciferase Reporter Assay (Promega, Madison, WI, USA). James M. Allan, D.Phil., the senior author of the study, said, "By testing for the risk variant of the CD95 gene, we should now be able to help doctors identify those vulnerable patients at high risk of either not responding to chemotherapy or developing potentially fatal side effects from their treatment. These patients can then be treated differently to minimize the risk of a poor response." The study was published on January 12, 2012, in the journal Blood.

Related Links:

Newcastle University
Enzo Life Sciences
Promega




PURITAN MEDICAL
ADVANCED INSTRUMENTS
GREINER-BIO-ONE
BioConferenceLive

Channels

Clinical Chemistry

view channel
Image: The ICON 25 hCG point-of-care pregnancy test (Photo courtesy of Beckman Coulter).

Pregnancy Tests Evaluated During Early Gravidity

The predominant hormone human chorionic gonadotropin (hCG) variant in urine, hCG β core fragment (hCGβcf), has been demonstrated to cause false-negative results in qualitative point-of-care (POC) hCG devices.... Read more

Hematology

view channel

Blood Donations Screened for Viruses Using Multiplex Assay

A global healthcare company was chosen to partner the Japanese Red Cross (JRC; Tokyo, Japan) for nucleic acid screening of the nation's blood supply. Under the terms of the 7-year agreement, the healthcare company, Grifols (Barcelona, Spain) will provide the JRC with its newest automation platform, the Procleix Panther... Read more

Pathology

view channel
Image: Immunostaining of human lung tissue, fixed with HOPE, from a patients suffering from legionnaire\'s disease. One legionella protein (red-brown), the bacteria-containing vacuoles and individual legionella inside the scavenger cells can be detected. The infection process can be observed immediately using proteomics (Photo courtesy of Braunschweig University of Technology).

Novel Method Prepares Tissue Samples for Analyzing Proteins

A new way of preparing patient tissue for analyses might soon become the new standard, possibly replacing tissues fixed with formalin, before they are embedded in wax-like paraffin and cut into razor-thin slices.... Read more

Industry News

view channel

Roche and Hitachi Renew Alliance in Diagnostics

Roche (Basel, Switzerland) and Hitachi (Tokyo, Japan) have renewed their alliance in the diagnostics business by 10-years for the joint development and manufacture of the next generation of instruments and workflow automation solutions for medical laboratories. The renewed alliance marks a significant milestone towards... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.