Features | Partner Sites | Information | LinkXpress
Sign In
FOCUS DIAGNOSTICS, INC.
RANDOX LABORATORIES
GLOBETECH PUBLISHING LLC

Blood Iron Test Predicts Fatal Outcomes

By Labmedica International staff writers
Posted on 14 Apr 2014
Image: The Coulter Electronic Counter (Photo courtesy of Beckman Coulter).
Image: The Coulter Electronic Counter (Photo courtesy of Beckman Coulter).
The transferrin saturation (TSAT) ratio is a commonly used indicator of iron deficiency and iron overload in clinical practice, but precise relationships with total and cardiovascular mortality are equivocal.

The test is a measure of the amount of available iron in the bloodstream with low levels generally reflecting a state of iron deficiency and high levels suggesting a relative excess which can be detrimental to health.

Scientists at the University of Limerick (Ireland) studied 15,823 participants, 20 years of age or older, who had a valid serum creatinine value. Serum creatinine values were used to determine the estimated glomerular filtration rate (eGFR) in mL/min/1.73 m2 for all participants. Blood samples were obtained from nonfasting persons and frozen serum sent for analysis.

Serum iron and total iron binding capacity were measured colorimetrically (Alpkem RFA analyzer; Clackamas, OR, USA), and serum ferritin was measured with the Quantimmune IRMA kit (Bio-Rad Laboratories; Hercules, CA, USA). Hemoglobin was measured using a Coulter S-Plus Jr electronic counter (Coulter Electronics; Hialeah, FL, USA). Serum creatinine concentrations were measured by the modified kinetic Jaffe reaction using a Hitachi 737 analyzer (Boehringer Mannheim Corp.; Indianapolis, IN, USA).

The study found that subjects with extremely low transferrin saturation levels of less that 17.5% were at a 45% higher risk of death. On the other hand, the risk of death was also significantly higher for subjects with very high levels of transferrin saturation above 31.3 %. The mean values for TSAT were 26.3 %; hemoglobin 14.2 g/dL and serum ferritin level 129 ng/mL. The association of TSAT with mortality differed by race and sex. Among whites and blacks, low and high TSAT levels were associated with higher mortality risk while no association was manifest in Mexican-Americans. For men, the impact on mortality was demonstrated only in older males, while for women the j-shaped mortality association was confined to younger females. High levels usually occur in states of iron overload like hemochromatosis, multiple blood transfusions and cirrhosis.

Austin G. Stack MD MSc, a professor and senior author of the study said, “Our analysis suggests that the optimal transferrin saturation range for patient survival should be between 23% to 40% and that careful clinical assessment is warranted for patients with low and high levels in order to identify states of iron deficiency or iron excess. Our study demonstrates that transferrin saturation ratio is a useful prognostic tool in assessing a patient's health and while we support the correction of low transferrin saturation levels in the general population, we would also advise caution against excessive iron loading to levels beyond 40%.” The study was published on March 5, 2014, in the Quarterly Journal of Medicine.

Related Links:

University of Limerick
Alpkem
Bio-Rad



DIASYS DIAGNOSTIC SYSTEMS
KARL HECHT GMBH & CO KG
77 ELEKTRONIKA

Channels

Genetic Tests

view channel
Image: The final result of a DNA sequencing process, with each color representing one of the four base chemicals, adenine, guanine, cytosine and thymine, that comprise DNA (Photo courtesy of Gerald Barber).

Gene Sequencing Reference Standard Increases Accuracy for Medical Laboratories

To reduce the variability in genetic test results that has been observed across different clinical laboratories and pathology groups, a new standard DNA reference has been introduced, which will improve... Read more

Hematology

view channel
Image: Immunochemistry of bone marrow biopsy from an acute myeloid leukemia patient showing sheets of CD34 positive cells; corresponding bone marrow aspirate showed only 20% blasts (Photo courtesy of All India Institute of Medical Sciences).

Immunohistochemistry Assesses Early Response in Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a heterogeneous disease with respect to prognosis and early response assessment has an established role as predictor of remission rate, and overall and disease-free survival.... Read more

Industry News

view channel

Partners to Develop and Commercialize Noninvasive Tests for Bladder Cancer

An agreement between a major European university medical center and a multinational biotechnology company was designed to promote commercialization and further development of a liquid biopsy test for the diagnosis of bladder cancer. The liquid biopsy test is based on bladder cancer DNA methylation biomarkers developed... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.