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Clinical Chemistry

Image: Capillary electrophoresis–mass spectrometry apparatus (Photo courtesy of the Dovichi Group).

Proteome-Based Marker Classifies Chronic Kidney Disease Progression

Chronic kidney disease (CKD) progression is currently assessed by a decline in estimated glomerular filtration rate (eGFR) and/or an increase in urinary albumin excretion (UAE) though these markers are considered either to be late-stage markers or to have low sensitivity or specificity. More...
26 Jul 2016

Exposure to Toxins in Children Associated with Kidney Disease Biomarker

Researchers have assessed environmental exposure to multiple toxins in children living in a region of Mexico with a high incidence of chronic kidney disease, especially among young adults. They not only detected high levels of arsenic and chromium in urine samples, they also detected elevated levels of Kidney Injury Molecule-1 (KIM-1), a biomarker currently being studied as an early sign of kidney injury. More...
26 Jul 2016

Common Circulating Cell Clusters in Cancer Patients Characterized Anew

In a study of blood samples from colorectal cancer patients, researchers have now discovered the source of these cells and that they are not malignant, potentially opening up a new path to detect and inhibit the spread of cancer. More...
25 Jul 2016
Image: The benchtop Picofox S2 total reflection X-ray fluorescence spectrometer (Photo courtesy of Bruker Nano).

Low Selenium Levels Linked to Liver Cancer Development

Selenium is a trace mineral micronutrient that is found in foods like shellfish, salmon, Brazil nuts, meat, eggs, grains, and onions. However, selenium levels in foods depend largely on the levels of selenium in the soil where the food is grown and animals graze. More...
21 Jul 2016
Image: The PLAC Test activity kit for measuring Lipoprotein-Associated Phospholipase A2 (Photo courtesy of diaDexus).

Lipoprotein-Associated Phospholipase A2 Tests Help Diagnose Heart Disease

The measurement of low-density lipoprotein cholesterol (LDL-C) or non-high-density lipoprotein cholesterol (non-HDL-C) is currently the mainstay when assessing the risk of atherosclerosis leading to cardiovascular disease. More...
19 Jul 2016
Image: According to new research, a blood test that leads to donor hearts being rejected may not effectively predict whether a heart transplant will succeed or fail (Photo courtesy of the AMA).

Heart Transplantation Recipients Unaffected by Donor Troponin Levels

Many transplant centers routinely reject hearts if the donor’s blood test reveals elevated levels of troponin I, a protein found in heart muscle that enters the bloodstream when there is a heart attack or other heart muscle damage. Donors with previous heart disease are automatically excluded. More...
14 Jul 2016
Image: The Thermo-Finnigan LTQ mass spectrometer (Photo courtesy of Thermo Fisher Scientific).

Plasma Mannose Levels May Indicate Diabetes Risk

Obesity is associated with an increased risk for a wide range of morbidities, including insulin resistance (IR), type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease (CVD). More...
14 Jul 2016


The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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