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Clinical Chemistry

Image: The Synergy multimode microplate reader ((Photo courtesy of BioTek Instruments).

Blood Analyses Predict Delirium Risk In Older Surgical Patients

Delirium, or sudden severe confusion due to rapid changes in brain function that can occur with physical or mental illness, affects 15% to 53% of older surgical patients and has been linked with longer hospital stays, greater postoperative complications, and higher rates of discharge to nursing homes. More...
26 May 2016
Image: Clinical manifestation of Homozygous Familial Hypercholesterolemia, interdigital xanthoma (Photo courtesy of the National Organization for Rare Disorders).

New Gene Associated With Familial High Cholesterol

The gene that explains one quarter of all familial hypercholesterolemia with very high blood cholesterol has been revealed. Familial hypercholesterolemia is the most common genetic disorder leading to premature death, found in 1 in 200 people. More...
26 May 2016

Elevated Chitotriosidase Differentially Diagnoses Lysosomal Storage Disorders

Plasma chitotriosidase originates from activated macrophages and is reported to be elevated in many Lysosomal Storage Disorders. Measurement of this enzyme’s activity has been an available tool for monitoring therapy of Gaucher disease. More...
25 May 2016

Microfluidic Chip Developed For Ultrasensitive Glucose Detection

Highly sensitive and rapid detection of blood glucose is a diagnostic necessity in medicine as, for instance, lack of insulin and too much blood sugar are two main causes of diabetes, both of which can be detected by measuring blood glucose. More...
18 May 2016

Infrared Technology Used To Screen For Minimally Invasive Colitis

Inflammatory bowel diseases, which include ulcerative colitis and Crohn's disease, involve chronic inflammation of all or part of the digestive tract and can lead to life-threatening complications such as colorectal cancer. More...
18 May 2016
Image: Dried blood spots are used to screen newborns for a number of rare inherited conditions. A new dried blood spot screening test has been developed for Niemann-Pick type C, a rare neurodegenerative condition that usually is not diagnosed until after damage to brain cells has begun (Photo courtesy of Washington University School of Medicine).

Newborn Screening Test Developed For Deadly Neurological Disorder

A newborn screening test has been introduced that identifies infants with Niemann-Pick disease type C, an often fatal condition in which cholesterol builds up and eventually destroys brain cells. More...
18 May 2016

Breath Test May Help Diagnose Irritable Bowel Syndrome

There is currently no specific diagnostic & monitoring test for irritable bowel syndrome (IBS) and no potentially reliable biomarkers have been identified until now. Using a novel metabolomic approach, researchers have identified a combination of substances in the breath that, when measured together, accurately distinguished IBS patients from people without the condition. More...
17 May 2016


The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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