We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
INTEGRA BIOSCIENCES AG

Download Mobile App




Study Explains Link between Genetic Variation and Vaccine Specificity and Persistence

By LabMedica International staff writers
Posted on 24 Jun 2019
Print article
Image: A micrograph of Neisseria meningitidis in cerebrospinal fluid (CSF) seen by Gram stain at 1000x magnification. Infection could be prevented by vaccination (Photo courtesy of Wikimedia Commons).
Image: A micrograph of Neisseria meningitidis in cerebrospinal fluid (CSF) seen by Gram stain at 1000x magnification. Infection could be prevented by vaccination (Photo courtesy of Wikimedia Commons).
To better explain how genetic variation affects antibody production and specificity following immunization, researchers conducted a GWAS (genome-wide association study) to examine the persistence of immunity following administration of three childhood vaccines.

The efficacy of vaccine-induced immunity depends on the considerable variability in magnitude and persistence of specific antibodies. Maintenance of these specific antibodies is essential for continuity of vaccine-induced serological protection.

Investigators at the University of Oxford (United Kingdom) conducted a genome-wide association study into the persistence of immunity to three childhood vaccines: capsular group C meningococcal (MenC), Haemophilus influenzae type b, and tetanus toxoid (TT) vaccines. Working with genetic data collected from 3,602 children in the United Kingdom and The Netherlands, the investigators analyzed approximately 6.7 million genetic variants affecting single nucleotide polymorphisms (SNPs) associated with vaccine-induced antibody levels.

Following analysis of the results, the investigators published detailed associations between variants in a locus containing a family of signal-regulatory proteins and the persistence of MenC immunity.

"Evoking robust and sustained vaccine-induced immunity from early life is a crucial component of global health initiatives to combat the burden of infectious disease," said first author Dr. Daniel O'Connor, postdoctoral researcher in pediatrics at the University of Oxford. "The mechanisms underlying the persistence of antibody are of major interest, since effectiveness and acceptability of vaccines would be improved if protection were sustained after infant immunization without the need for repeated boosting through childhood."

The vaccine study was published in the June 11, 2019, online edition of the journal Cell Reports.

Related Links:
University of Oxford

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Specimen Collection & Transport
Complement 3 (C3) Test
GPP-100 C3 Kit
Gold Member
ADAMTS-13 Protease Activity Test
ATS-13 Activity Assay

Print article

Channels

Clinical Chemistry

view channel
Image: Reaching speeds up to 6,000 RPM, this centrifuge forms the basis for a new type of inexpensive, POC biomedical test (Photo courtesy of Duke University)

POC Biomedical Test Spins Water Droplet Using Sound Waves for Cancer Detection

Exosomes, tiny cellular bioparticles carrying a specific set of proteins, lipids, and genetic materials, play a crucial role in cell communication and hold promise for non-invasive diagnostics.... Read more

Molecular Diagnostics

view channel
Image: The cobas Malaria test is the first FDA-approved molecular test to screen U.S. blood donors for malaria (Photo courtesy of Roche)

First FDA-Approved Molecular Test to Screen Blood Donors for Malaria Could Improve Patient Safety

Malaria, a serious illness that often leads to death, is spread by a specific mosquito species that infect humans with a parasite. Other transmission modes include blood transfusions, organ transplants,... Read more

Hematology

view channel
Image: The low-cost portable device rapidly identifies chemotherapy patients at risk of sepsis (Photo courtesy of 52North Health)

POC Finger-Prick Blood Test Determines Risk of Neutropenic Sepsis in Patients Undergoing Chemotherapy

Neutropenia, a decrease in neutrophils (a type of white blood cell crucial for fighting infections), is a frequent side effect of certain cancer treatments. This condition elevates the risk of infections,... Read more

Pathology

view channel
Image: The medical office procedure detects the key biomarker in Parkinson’s and related neurodegenerative diseases (Photo courtesy of BIDMC)

Simple Skin Biopsy Test Detects Parkinson’s and Related Neurodegenerative Diseases

Parkinson's disease and a group of related neurodegenerative disorders known as synucleinopathies impact millions globally. These conditions, including Parkinson’s disease (PD), dementia with Lewy bodies... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.