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Lab Tech.

Image: A peripheral blood film from a patient with sickle cell disease (Photo courtesy of Venngage).

New Method Rapidly Monitors Sickle Cell Disease

Sickle cell disease (SCD) is a hereditary disorder that affects red blood cells, distorting their natural disc shape into a crescent moon or "sickle" shape. Normal red blood cells move freely through small vessels throughout the body to deliver oxygen. With sickle cell disease, the misshapen red blood cells become hard and sticky, making it difficult for them to move through blood vessels. More...
26 Jun 2019
Image: Examples of migratory and non-migratory MDA-MB-231 breast cancer cells migrating in the MAqCI (Microfluidic Assay for quantification of Cell Invasion) device (Photo courtesy of Christopher L. Yankaskas, Johns Hopkins University).

Microfluidic Motility Device Indicates Likelihood of Breast Tumor Metastasis

A novel microfluidic motility test was shown to accurately predict a breast tumor's likelihood to generate metastases. More...
10 Jun 2019
Image: A diagram of the 3D-printed microchip electrophoresis device that can sensitively detect three serum biomarkers of preterm birth (Photo courtesy of Brigham Young University).

3D-Printed Device Detects Biomarkers of Preterm Birth

Preterm birth (PTB), defined as birth before the 37th week of gestation, is the leading complication of pregnancy and it affects about 1 in 10 pregnancies worldwide. Preterm infants can suffer complications such as neurological, respiratory and cardiac problems and, in some cases, even death. More...
06 Jun 2019
Image: The unique pipette tip created with a 3D printer to perform enzyme-linked immunosorbent assays (Photo courtesy of the University of Connecticut).

Novel 3D-Printed Technology Lowers Cost of ELISA

Traditional enzyme-linked immunosorbent assay (ELISA) tests are performed on plates featuring 96 micro-wells; each well works as a separate testing chamber where samples can be combined with various agents that will then react with the sample, typically by changing color. More...
06 Jun 2019
Image: Bioimpedance spectroscopy (BIS) is better than a tape measure for assessing a woman’s risk for developing lymphedema after breast cancer surgery, according to interim results of a study (Photo courtesy of Vanderbilt University School of Nursing).

Bioimpedance Spectroscopy Preferred for Post-Breast Surgery Lymphedema Risk

Interim results from a study that compared bioimpedance spectroscopy (BIS) to the classical tape measure for assessing a woman’s risk for developing lymphedema after breast cancer surgery strongly suggested that BIS was the preferred method. More...
04 Jun 2019
Image: Left: Images of a blebbing, highly metastatic PC3 prostate cancer cell (top) and a non-blebbing normal RWPE-1 prostate cell being forced into a microfluidic channel. Middle: Outlines of the images on the left highlighting blebbing and cell deformation. Right: Percentage of highly metastatic PC3, moderately metastatic DU145, and normal RWPE-1 cells that bleb while being forced into a channel along with the standard deviation (SD) (Photo courtesy of Fazle Hussain, Texas Tech University).

Increased Bleb Formation Characterizes Metastatic Cancer Cells

A recent paper described an inexpensive fluid biopsy device that is able to distinguish highly metastatic prostate cancer cells from moderately metastatic prostate cancer cells and normal cells. More...
04 Jun 2019
Image: An instrument used for manufacturing test strips to measure stress biomarkers (Photo courtesy of Andrew Higley, University of Cincinnati).

Novel Stress Biomarker Measurement Method Uses UV Range

A recent paper described a novel label-free method for quantitative detection of human performance “stress” biomarkers in different body fluids that is based on optical absorbance of biomarkers in the ultraviolet (UV) range of the spectrum. More...
04 Jun 2019

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