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Image: Vascular cell adhesion protein 1 (VCAM‐1) enzyme-linked immunosorbent assay kit (Photo courtesy of PerkinElmer).

Biomarkers Linked to Fatigue in Parkinson’s Disease

Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms generally come on slowly over time. Early in the disease, the most obvious are shaking, rigidity, slowness of movement, and difficulty with walking. More...
21 Aug 2018
Image: The ARCHITECT i2000SR immunoassay analyzer (Photo courtesy Abbott Diagnostics).

Fifth-Generation Cardiac Troponin Assays Compared

Cardiac troponin I (cTnI) and cardiac troponin T (cTnT) are highly specific biomarkers of myocardial injury. The 99th percentile upper reference limit (URL) of a normal reference population is the recommended threshold which defines an increased cTnI or cTnT plasma concentration indicative for myocardial injury. More...
20 Aug 2018
Image: Positive and negative results detected by the lateral flow immunochromatographic assay AcQuickDx test for Angiostrongylus cantonensis (Photo courtesy of Faculty of Medicine Siriraj Hospital).

Immunochromatographic Test Rapidly Diagnoses Parasitic Infection

The rat lungworm Angiostrongylus cantonensis is a food-borne zoonotic parasite that causes eosinophilic meningitis in humans. Suspected cases of A. cantonensis infection can only be confirmed by finding the nematodes in cerebral spinal fluid (CSF) of the patients. More...
15 Aug 2018
Image: The figure illustrates how T cells are detected in a blood sample with Epiontis ID. In T cells, the CD3 gene region is epigenetically active (yellow); in all other cell types, this region is epigenetically inactive (blue). The number of epigenetically active CD3 gene copies directly translates to the number of T cells in the sample (Photo courtesy of Precision for Medicine).

Epigenetic Diagnostic Tool Detects Diseases in Newborns

Newborns are routinely screened for inheritable diseases by analyzing dried blood spots (DBS) from blood taken from a heel-prick. Among the more than 300 known primary immune deficiencies (PIDs), only Severe Combined Immunodeficiencies (SCID) are detected at birth with the current technology used to analyze the DBS. More...
13 Aug 2018
Image: A photomicrograph of squamous-cell carcinoma, a type of non-small-cell carcinoma of the lung, from a fine needle aspiration specimen (Photo courtesy of Nephron).

Cancer Risk Assessed by Circulating Protein Biomarker Panel

The question has been asked whether a risk prediction model based on circulating protein biomarkers improve on a traditional risk prediction model for lung cancer and the current USA screening criteria. More...
10 Aug 2018
Image: The ACL AcuStar testing analyzer offers full automation of highly sensitive immunoassays (Photo courtesy of Instrumentation Laboratory).

IgM Antibodies Improve Risk Stratification for Antiphospholipid Syndrome

The antiphospholipid syndrome (APS) is an autoimmune hypercoagulable state and is characterized by thrombosis and/or pregnancy morbidity with the persistent presence of antiphospholipid antibodies (aPL). More...
08 Aug 2018
Image: A photomicrograph of pigmented malignant melanoma in a Papanicolaou stained cytology specimen, (Photo courtesy of Nephron).

Melanoma Biomarkers Predict Checkpoint Blocker Response

The outlook for patients with advanced melanoma has dramatically improved in recent years because of drugs known as immune checkpoint inhibitors, which mobilize the immune system to attack cancer. These drugs block checkpoint molecules that act as brakes on the immune system and unleash immune defenders such as T cells to recognize and attack cancer. More...
02 Aug 2018

The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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