We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
INTEGRA BIOSCIENCES AG

Download Mobile App




Events

09 Apr 2024 - 12 Apr 2024
15 Apr 2024 - 17 Apr 2024
23 Apr 2024 - 26 Apr 2024

Five-Gene Signature Predicts Survival from Renal Cell Carcinoma

By LabMedica International staff writers
Posted on 20 Mar 2019
Print article
Image: A histopathology of clear cell papillary renal cell carcinoma (Photo courtesy of Nephron).
Image: A histopathology of clear cell papillary renal cell carcinoma (Photo courtesy of Nephron).
Papillary renal cell carcinomas include type 1 lesions, which are characterized by small cells in single layers and scanty cytoplasm and type 2 lesions, which are distinguished by larger cells, pseudo-stratified nuclei, and voluminous eosinophilic cytoplasm.

Though the exact cause of papillary renal cell carcinoma is unknown, smoking, obesity, and genetic predisposition conditions such as hereditary leiomyomatosis and renal cell cancer may contribute to the development of this type of cancer. It accounts for about 10% to 15% of all renal cell carcinomas.

Urologists at the Qilu Hospital of Shandong University (Jinan, China) and their associates investigated the gene expression changes in papillary renal cell carcinoma (pRCC) and screen several genes and associated pathways of pRCC progression. They downloaded the pRCC RNA sequencing (RNA-seq) data set from The Cancer Genome Atlas (TCGA). They identified the differentially expressed messenger RNA (mRNA) between cancer and normal tissues and performed annotation of differentially expressed mRNAs to figure out the functions and pathways they were enriched in. Then, they constructed a risk score that relied on 5-mRNAs.

Based on differentially expressed gene in high-risk cases, the investigators found five survival-related genes, CCNB2, IGF2BP3, KIF18A, PTTG1, and BUB1, that could distinguish 53 high-risk pRCC patients from 89 low-risk patients in a subsequent validation analysis. The study revealed the 5-mRNA expression profile and the potential function of a single mRNA as a prognostic target for papillary renal cell carcinoma.

The authors concluded that by performing a comprehensive analysis for differentially expressed mRNA profiles and corresponding clinical information, the study demonstrated that 5-mRNA signature was a potential diagnostic marker in pRCC, and was an independent prognostic factor in pRCC patients. This signature has a lot of potential prognostic and therapeutic implications for the pRCC patient management. The study was published on March 1, 2019, in the journal PLoS ONE.

Related Links:
Qilu Hospital of Shandong University

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Specimen Collection & Transport
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
Gold Member
ADAMTS-13 Protease Activity Test
ATS-13 Activity Assay

Print article

Channels

Clinical Chemistry

view channel
Image: Reaching speeds up to 6,000 RPM, this centrifuge forms the basis for a new type of inexpensive, POC biomedical test (Photo courtesy of Duke University)

POC Biomedical Test Spins Water Droplet Using Sound Waves for Cancer Detection

Exosomes, tiny cellular bioparticles carrying a specific set of proteins, lipids, and genetic materials, play a crucial role in cell communication and hold promise for non-invasive diagnostics.... Read more

Hematology

view channel
Image: The low-cost portable device rapidly identifies chemotherapy patients at risk of sepsis (Photo courtesy of 52North Health)

POC Finger-Prick Blood Test Determines Risk of Neutropenic Sepsis in Patients Undergoing Chemotherapy

Neutropenia, a decrease in neutrophils (a type of white blood cell crucial for fighting infections), is a frequent side effect of certain cancer treatments. This condition elevates the risk of infections,... Read more

Pathology

view channel
Image: The medical office procedure detects the key biomarker in Parkinson’s and related neurodegenerative diseases (Photo courtesy of BIDMC)

Simple Skin Biopsy Test Detects Parkinson’s and Related Neurodegenerative Diseases

Parkinson's disease and a group of related neurodegenerative disorders known as synucleinopathies impact millions globally. These conditions, including Parkinson’s disease (PD), dementia with Lewy bodies... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.