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Clinical Chemistry

Image: An illustration of Coll2-1, a marker specific of type II collagen degradation in osteoarthritis (Photo courtesy of Artialis).

Specific Biomarker Assessed for Cartilage Degradation

Osteoarthritis (OA) is one of the most common forms of musculoskeletal disorders and one of the major causes of pain and disability in the adult population. Viscosupplementation is a symptomatic treatment of the knee osteoarthritis based on the intra-articular injection of hyaluronic acid (IAHA). More...
21 Jun 2017
Image: A new study shows pre-op serum cholesterol level may have a significant impact with prognosis in renal cell carcinoma patients (Photo courtesy of Getty Images).

Pre-Op Cholesterol Level Predicts RCC Patients Survival

Renal cell carcinoma (RCC) is the most frequently diagnosed renal malignancy. The constant advances of modern imaging technologies and the percentage of incidentally detected renal tumors has constantly increased during the last couple of decades, and a good percentage of patients are still diagnosed with metastatic renal cell carcinoma (mRCC). More...
21 Jun 2017
Image: The Quo-Test HbA1c fully automated analyzer uses patented boronate fluorescence quenching technology to measure glycated hemoglobin from a 4 μL sample taken from a finger prick or venous whole blood (Photo courtesy of EKF Diagnostics).

POC Analyzer Compared with HPLC Method

The measurement of the glycated fraction of hemoglobin (HbA1c) has been recommended to diagnose diabetes, in addition to monitoring glycemic control. HbA1c reflects long-term glycemic control over the preceding two to three months as opposed to glycemic control at a single point in time. More...
20 Jun 2017
Image: The Videssa Breast protein biomarker blood test for breast cancer evaluates 11 serum protein biomarkers and 33 tumor-associated autoantibodies (Photo courtesy of Provista Diagnostics).

Blood Test Offers Improved Breast Cancer Detection

Breast cancer is predicted to be the second leading cause of cancer deaths in the USA women. Approximately 232,000 cases of invasive breast cancer and 60,000 cases of ductal carcinoma in situ (DCIS) are diagnosed and 40,000 deaths occur annually. More...
16 Jun 2017
Image: The Sgx Clarity system, an integrated single molecule counting technology-reading instrument (Photo courtesy of Singulex).

Cardiac Troponin Test Uses Single Molecule Counting Technology

Coronary artery disease (CAD) is the leading cause of death worldwide and a significant proportion of ambulatory health care visits are for evaluation of patients with suspected CAD, with an estimated 1.5% of the population presenting with chest pain every year. More...
13 Jun 2017
Image: The UniCel DxI 800 immunoassay system (Photo courtesy of Beckman Coulter).

Thyroid Disorders Affect Circulating TRAIL Levels

A circulating protein called TNF-related apoptosis-inducing ligand (TRAIL) might have a role in the regulation of body weight and metabolism. Interestingly, thyroid hormones seem to increase TRAIL tissue expression. More...
12 Jun 2017
Image: An overview of tooth-matrix biomarkers applied in this study (Photo courtesy of Arora M et al / Nature Communications).

Baby Teeth Reveal Association Between Autism and Metals

Analyzing fetal and postnatal teeth, researchers have found that levels of specific metal nutrients and toxins during pregnancy and early childhood is correlated with risk of developing autism spectrum disorders (ASD). Both amount and timing of abnormal levels can affect risk and diagnosis. More...
12 Jun 2017


The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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