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Clinical Chemistry

Image: The LC UltiMate 3000 high performance liquid chromatography (HPLC) system coupled with an LTQ Velos Pro mass spectrometry system (Photo courtesy of Thermo Fisher Scientific).

New Methods Developed to Diagnose TB and HIV

The bacteria responsible for tuberculosis (TB) can lurk in a person's lung tissue for decades before producing active, infectious TB disease and it is estimated that a third of the global population may have such dormant infections, with 5% to 10% progressing to active disease. Detecting TB is notoriously challenging. More...
15 Nov 2017
Image: A range of Elecsys and cobas Reagents for thyroid function test kits (Photo courtesy of Roche).

High Thyroid Hormone Levels Associated with Arterial Disease

Atherosclerosis is the process of progressive thickening and hardening of the walls of arteries from fat deposits on their inner lining. Atherosclerosis progresses insidiously from a subclinical condition to the clinical onset of vascular events to death. More...
15 Nov 2017
ELITech Group
Image: An immunohistochemistry of the new biomarker DNAJB9 greatly improves diagnostic sensitivity for the rare kidney disease, fibrillary glomerulonephritis (Photo courtesy of Mayo Clinic).

Potential Autoantigen Identified in Aggressive Kidney Disease

Fibrillary glomerulonephritis (FGN) is an aggressive kidney disease, and nearly half of patients become dependent on dialysis within several years of diagnosis. No unique clinical markers of FGN have been identified to help diagnose FGN, and current tests involve time-consuming analyses with light microscopy, immunofluorescence, and electron microscopy. More...
13 Nov 2017
Image: The rapid Quantum Blue Fecal Calprotectin lateral flow test (Photo courtesy of Bühlmann Laboratories).

Fecal Calprotectin Predicts Complete Mucosal Healing in UC

Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterized by a disease course involving relapses and remissions. Historically, clinical remission was the major treatment target for patients with UC. More...
13 Nov 2017
Image: The OC-Sensor apparatus used for the quantitative fecal immunochemical test screening for colorectal cancer (Photo courtesy of Eiken).

FIT Hemoglobin Predicts Risk of Advanced Neoplasia

Colorectal cancer (CRC) screening using quantitative fecal immunochemical tests (FITs) is rapidly gaining ground worldwide and FITs are invariably used in a dichotomous manner using pre-specified cut-off values. More...
09 Nov 2017
Image: The Videssa Breast is the first blood test of its kind that detects and analyzes multiple types of tumor protein biomarkers for improved cancer detection (Photo courtesy of Provista Diagnostics).

Blood Test Can Effectively Rule Out Breast Cancer

Breast density is associated with reduced imaging resolution in the detection of breast cancer. Breast density is a radiologic phenomenon that is not discernable by palpation; it is a radiologist’s assessment. Imaging rays permeate dense breast tissue in a more opaque manner, thereby reducing image resolution. More...
07 Nov 2017
Image: An illustration of individual breast cancer tumors (Tumors A–D) with cells in varying differentiation states (shown in different colors) within a tumor (Image courtesy of Yeo SK and Guan J-L / Trends in Cancer).

Single-Cell Diagnostics Advocated for Breast Cancer Subtyping

In an opinion article based their analysis of studies, two medical researchers argue that women diagnosed with breast cancer (BC) would likely benefit from treatment based also on identifying the molecular subtype of different cells within their tumors, in addition to current molecular and histopathology testing of collections of tumor cells. More...
06 Nov 2017

The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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