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Image: Bone marrow smear from a patient with refractory anemia (MDS) with ring sideroblasts. Classic appearance of ring sideroblasts shows iron deposition in a `necklace` around the nucleus using Perls stain (Photo courtesy of University of Pavia)

Hematological and Molecular Parameters Defined for CCUS and MDS

Patients with clonal cytopenia of undetermined significance (CCUS) have low blood counts and a normal bone marrow examination, but more advanced genetic testing shows the presence of a genetic mutation that is likely causing the low counts. More...
11 May 2021
Image: Histology showing pathological and immunopathological findings from a spinal cord lesion from a 52-year-old woman who died from active neuromyelitis optica associated with a longitudinally extensive spinal cord lesion extending from C3 to T8 (Photo courtesy of CHU de Strasbourg)

African-American MS Patients Experience More Rapid B-Cell Repopulation

Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord (central nervous system). In MS, the immune system attacks the protective sheath (myelin) that covers nerve fibers and causes communication problems between the brain and the rest of the body. More...
06 May 2021
Image: B cell–activating factor modulates the factor VIII immune response in hemophilia A (Photo courtesy of Children’s Hospital of Philadelphia)

Cytokine Target Identified for Treatment-Resistant Hemophilia A

Hemophilia A, also called factor VIII (8) deficiency or classic hemophilia, is a genetic disorder caused by missing or defective factor VIII (FVIII), a clotting protein. Although it is passed down from parents to children, about 1/3 of cases found have no previous family history. More...
04 May 2021
Image: The CytoFLEX Flow Cytometer has a large dynamic range to resolve dim and bright populations in the same sample (Photo courtesy of Beckman Coulter)

Synovial Fluid Neutrophils Phenotyped in Oligoarticular Juvenile Idiopathic Arthritis

Juvenile idiopathic arthritis (JIA) is an inflammatory rheumatic joint disease affecting children. Despite disease onset being at a young age, symptoms may be lifelong and include irreversible joint damage or growth disturbances. More...
29 Apr 2021
Image: The QX200 Droplet Digital Polymerase Chain Reaction (PCR) Systems provide ultrasensitive and absolute nucleic acid quantification. (Photo courtesy of Bio-Rad)

Digital PCR Improves BCR-ABL1 Detection in Chronic Myeloid Leukemia

Specific targeting of the Bcr-Abl1 enzyme by tyrosine kinase inhibitors (TKI) revolutionized the management of chronic myeloid leukemia (CML) to the point that TKIs can offer near normal life expectancy for CML patients. More...
22 Apr 2021
Image: BD FACSCanto II flow cytometer (Photo courtesy of BD Biosciences)

Tissue Counterpart to Monoclonal B-Cell Lymphocytosis Characterized

Monoclonal B-cell lymphocytosis (MBL) was initially proposed to recognize patients with a monotypic B cell population identified by peripheral blood (PB) flow cytometry (FC) that did not meet numerical criteria for chronic lymphocytic leukemia (CLL). More...
21 Apr 2021
Image: Histology comparison of airway features in (A) a healthy individual and (B) in a patient with chronic obstructive pulmonary disease where airways are narrowed by infiltration of inflammatory cells, mucosal hyperplasia, and deposition of connective tissue in the peribronchiolar space (Photo courtesy of University of Leuven)

Coagulation Dysfunction and Infection Evaluated in Patients with AECOPD

Chronic obstructive pulmonary disease (COPD) is one of the common chronic airway obstructive diseases, characterized by persistent respiratory symptoms and airflow limitation. In acute exacerbation stage (AECOPD), patients developed respiratory failure often have circulatory and coagulation dysfunction, which was considered the cause of thrombosis events in the patients. More...
14 Apr 2021

The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.
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