We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Microbiome and Metabolome Features Characterized for the Cardiometabolic Disease Spectrum

By LabMedica International staff writers
Posted on 28 Feb 2022
Print article
Image: The BD Accuri C6 Plus Flow Cytometer (Photo courtesy of BD Biosciences)
Image: The BD Accuri C6 Plus Flow Cytometer (Photo courtesy of BD Biosciences)

Scientists have already discovered that the gut microbiome is altered in people with chronic heart disease. They subsequently identified compounds that are produced by the diseased microbiome, for instance a bacterial compound called trimethylamine (TMA) that after modification in the liver of the human host causes arteriosclerosis.

The human gut contains trillions of bacteria, collectively called the gut microbiome, which may have positive and negative effects on human health. When in balance they function as an inner chemistry factory producing numerous compounds that promote good health.

However, an unhealthy lifestyle can disrupt the balance, leading the microbiome to instead produce compounds that may trigger multiple non-communicable chronic disorders in people at high genetic risk, including myocardial infarction, angina or heart failure. Scientists have already discovered that the gut microbiome is altered in people with chronic heart disease.

A large team of international scientists including those at the University of Copenhagen (Copenhagen, Denmark) recruited 1,241 middle-aged people from Denmark, France and Germany including healthy individuals, individuals with obesity and type 2 diabetes, but lacking a diagnosis of heart disease, and patients with either myocardial infarction, angina pectoris or heart failure. Fasting plasma glucose, total and HDL cholesterol, triglycerides, creatinine and HbA1c levels were measured using standard enzymatic methods.

Alanine aminotransferase, aspartate aminotransferase and γ-glutamyltransferase were measured by enzyme-coupled kinetic assays. Ultra-sensitive C-reactive protein was measured using an Image Automatic Immunoassay System (Beckman Coulter, Brea, CA. USA). Microbial loads of fecal samples were processed and analyzed using a C6 Accuri flow cytometer (BD Biosciences, San Diego, CA, USA).

The scientists found that about 75% of microbiome and metabolome features that distinguish individuals with ischemic heart disease (IHD) from healthy individuals after adjustment for effects of medication and lifestyle are present in individuals exhibiting dysmetabolism, suggesting that major alterations of the gut microbiome and metabolome might begin long before clinical onset of IHD. They further categorized microbiome and metabolome signatures related to prodromal dysmetabolism; specific to IHD in general or to each of its three subtypes or related to escalation or de-escalation of IHD. At higher microbiome architecture levels, there was a significant shift from the Bacteroides 1 and Ruminococcus enterotypes toward the low bacterial cell-count-associated Bacteroides 2 as the disease worsened.

Oluf Borbye Pedersen, MD, A Clinical Professor and a senior author of the study, said, “We found that about half of these gut bacteria and blood compounds were modified by drug treatment and not directly related to heart disease or the early disease stages like diabetes or obesity occurring prior to diagnosis of heart disease. Among the remaining half, about 75% of the disturbances of the gut microbiome occurred in the early disease stages of overweight and type 2 diabetes, many years before patients noticed any symptoms of heart disease.”

The authors concluded that at prodromal dysmetabolic stages and at both early and late clinical manifestations of IHD, multiple de-confounded microbiome and metabolome alterations are present, reflecting distinct metabolic pathways. Several of these are modifiable and might be targets for future mechanistic studies and clinical trials aiming at IHD prevention. The study was published on February 17, 2022 in the journal Nature Medicine.

Related Links:
University of Copenhagen 
Beckman Coulter
BD Biosciences 

Automated ELISA-IFA-BLOT Processor AP 22
Gold Supplier
Rheumatoid Factors (RF) Test
Rheumatoid Factors (RF)
Gold Supplier
pHOx Analyzer
BioProfile pHOx Analyzer
Automatic Specific Protein Analyzer
PA 900

Print article


Molecular Diagnostics

view channel
Image: A new method reliably detects protein changes in blood that are typical of Parkinson`s disease (Photo courtesy of Pexels)

First-Ever Blood Test Detects Parkinson’s Disease

Until now, the diagnosis of Parkinson's disease has been based primarily on typical movement disorders such as muscle stiffness, slower movements and shaking. However, the disease starts up to 20 years... Read more


view channel
Image: Fujirebio has acquired ADx NeuroSciences for 40 million Euros (Photo courtesy of Pexels)

Fujirebio Acquires ADx NeuroSciences to Speed Development of Neurodegenerative Diseases Diagnostic Tests

Fujirebio Holdings, Inc. (Tokyo, Japan) has announced the acquisition of ADx NeuroSciences (Gent, Belgium) for EUR 40 million in a deal that is expected to close in July 2022, pending the satisfaction... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.