New Device Detects Viruses Like COVID-19 in the Body as Fast as Rapid Tests With 95% Accuracy

Researchers have developed a device that detects viruses like COVID-19 in the body as fast as and more accurately than current, commonly used rapid detection tests.

The optical sensor developed by researchers at the University of Central Florida (UCF; Orlando, FL, USA) uses nanotechnology to accurately identify viruses in seconds from blood samples. Researchers say the device can tell with 95% accuracy if someone has a virus, a significant improvement over current rapid tests that experts warn could have low accuracy. Testing for viruses is important for early treatment and to help stop their spread. The researchers tested the device using samples of Dengue virus, a mosquito transmitted pathogen that causes Dengue fever and is a threat to people in the tropics. However, the technology can easily be adapted to detect other viruses, like COVID-19.

The device closely matches the accuracy of the gold-standard PCR-based tests but with nearly instantaneous results instead of results that take several days to receive. Its accuracy is also a significant improvement over current rapid antigen tests that the U.S. Food and Drug Administration and U.S. Centers for Disease Control have cautioned could produce inaccurate results if viral loads are low or test instructions are not properly followed. The device works by using nano-scale patterns of gold that reflect back the signature of the virus it is set to detect in a sample of blood. Different viruses can be detected by using different DNA sequences that selectively target specific viruses.

The key to the device’s performance is that it can detect viruses directly from blood samples without the need for sample preparation or purification, thus speeding up the test and improving its accuracy. The researchers confirmed the device’s effectiveness with multiple tests that used different virus concentration levels and solution environments, including those with the presence of non-target virus biomarkers. The next steps for the researchers include adapting the device to detect more viruses.

“The sensitive optical sensor, along with the rapid fabrication approach used in this work, promises the translation of this promising technology to any virus detection including COVID-19 and its mutations with high degree of specificity and accuracy,” said study co-author Debashis Chanda, a professor in UCF’s NanoScience Technology Center. “Here, we demonstrated a credible technique which combines PCR-like genetic coding and optics on a chip for accurate virus detection directly from blood.”

“Although there have been previous optical biosensing demonstration in human serum, they still require off-line complex and dedicated sample preparation performed by skilled personnel — a commodity not available in typical point of care applications,” said Abraham Vazquez-Guardado, the study’s lead author and a postdoctoral fellow at Northwestern University who worked on the research as a doctoral student in Chanda’s lab. “This work demonstrated for the first time an integrated device which separated plasma from the blood and detects the target virus without any pre-processing with potential for near future practical usages.”

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