We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Abbott Diagnostics- Hematology Division

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
20 Oct 2021 - 22 Oct 2021
21 Oct 2021 - 24 Oct 2021
Virtual Venue

Acute Lymphoblastic Leukemia Risk Linked to Genetically Mediated Increase in Lymphocytes

By LabMedica International staff writers
Posted on 15 Sep 2021
Print article
Image: Acute lymphoblastic leukemia: bone marrow aspirate smear reveals increased blasts which are small to medium in size with high nuclear-to-cytoplasmic ratios, round to irregular nuclei, smooth chromatin, and scant basophilic agranular cytoplasm. Some background maturing myeloid cells are also present in this case (Photo courtesy of Karen M. Chisholm, MD, PhD)
Image: Acute lymphoblastic leukemia: bone marrow aspirate smear reveals increased blasts which are small to medium in size with high nuclear-to-cytoplasmic ratios, round to irregular nuclei, smooth chromatin, and scant basophilic agranular cytoplasm. Some background maturing myeloid cells are also present in this case (Photo courtesy of Karen M. Chisholm, MD, PhD)
Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes. As an acute leukemia, ALL progresses rapidly and is typically fatal within weeks or months if left untreated.

ALL is the most common cancer among children under 15 years old and is thought to develop under a two-hit model, under which a preleukemic clone develops in utero and a second somatic mutation then spurs the development of leukemia. While some genetic risk loci linked to ALL include variants in genes that have also been associated with hematopoiesis, lymphoid development, and blood-cell traits.

Genetic Epidemiologists at the University of Southern California (Los Angeles, CA, USA) and their colleagues investigated the etiological relevance of dysregulated blood-cell homeostasis in a genome-wide association study (GWAS) of childhood ALL (2,666 affected individuals, 60,272 control individuals) and a multi-trait GWAS of nine blood-cell indices in the UK Biobank. They examined blood cell traits such as lymphocyte, platelet, and neutrophil counts, as well as neutrophil-to-lymphocyte ratios and platelet-to-lymphocyte ratios.

The investigators reported that about 3,000 genetic variants were associated with one or more of these hematological traits and explained between 4% and nearly 24% of the variation in those traits. Additionally, 115 loci were linked to blood-cell ratios. They uncovered positive correlations between increased lymphocyte counts, lymphocyte-to-monocyte ratio, and neutrophil levels with ALL risk, and an inverse correlation between a higher platelet-to-lymphocyte ratio and ALL risk.

A clustering analysis identified two putative novel ALL risk variants from among those associated with blood cell traits, one on chromosome 2q22.1 and one within the FLT3 gene on 13q12.2. The scientists noted that variants within FLT3 have recently been linked to an increased risk of autoimmune thyroid disease and acute myeloid leukemia (AML). The allele linked to both ALL and AML risk lead to a truncated FLT3 protein, but an increase in FLT3 ligand levels. While this variant has a greater effect on the development of myeloid cells, they said it could also affect ALL risk through its activation of the RAS/MAPK pathway.

The authors concluded that their study showed that a genetically induced shift toward higher lymphocyte counts, overall and in relation to monocytes, neutrophils, and platelets, confers an increased susceptibility to childhood ALL. The study was published on August 31, 2021 in the American Journal of Human Genetics.

Related Links:
University of Southern California

Gold Supplier
NEW PRODUCT : SILICONE WASHING MACHINE TRAY COVER WITH VICOLAB SILICONE NET VICOLAB®
REGISTRED 682.9
New
Real Time PCR Platform
VIASURE V-Lab96
New
Automated Capillary Electrophoresis System
CAPILLARYS 3 OCTA
New
qPCR Instrument
Q qPCR Instrument

Print article

Channels

Clinical Chem.

view channel
Image: Simoa is an ultra-sensitive immunoassay technology that allow detection of proteins and nucleic acids at lowest possible levels (Photo courtesy of Quanterix)

Plasma Amyloid-β 42/40 Assays Compared in Alzheimer Disease

Blood-based tests for brain amyloid-β (Aβ) pathology are needed for widespread implementation of Alzheimer disease (AD) biomarkers in clinical care and to facilitate patient screening and monitoring of... Read more

Molecular Diagnostics

view channel
Image: The QuikRead go iFOBT is an immunochemical fecal immunochemical test for detection and quantification of human hemoglobin in feces in case of suspected bleeding from the lower gastrointestinal tract (Photo courtesy of Aidian)

Fecal Immunochemical Tubes Sourced to Analyze Gut Microbiome for CRC

Colorectal cancer (CRC) is a challenging public health problem which successful treatment depends on the stage at diagnosis. Recently, CRC-specific microbiome signatures have been proposed as a marker... Read more

Immunology

view channel
Image: The BD LSRFortessa X-20 Cell Analyzer can be configured with up to five lasers to detect up to 20 parameters simultaneously to support ever increasing demands in multicolor flow cytometry (Photo courtesy of BD Biosciences)

Highly Multiplexed Cell Surface Protein Analyzed Via Flow Cytometry

Modern immunologic studies increasingly requires high-dimensional analyses to understand the complex milieu of cell types that comprise the tissue microenvironments of disease. One of the cornerstones... Read more

Pathology

view channel
Image: Characteristic bronchoalveolar lavage findings of diffuse alveolar hemorrhage (Photo courtesy of Peter C. Bauer, MD)

Bronchoalveolar Lavage Cell Pattern Determined for Diffuse Alveolar Hemorrhage

Diffuse alveolar hemorrhage (DAH) is a clinicopathological syndrome that describes the accumulation of intra-alveolar red blood cells originating from the alveolar capillaries. DAH can induce severe respiratory... Read more

Industry

view channel
Image: GastroPanel Quick Test (Photo courtesy of Biohit Healthcare)

Biohit’s Innovative GastroPanel Quick Test Receives CE Mark

Biohit Healthcare’s (Helsinki, Finland) GastroPanel Quick Test, the latest innovation in its unique GastroPanel product family, is now CE marked. The GastroPanel Quick Test is intended for diagnosing... Read more
Copyright © 2000-2021 Globetech Media. All rights reserved.