We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




Events

09 Apr 2024 - 12 Apr 2024
15 Apr 2024 - 17 Apr 2024
23 Apr 2024 - 26 Apr 2024

Gene Genomic Prostate Score Test Evaluated as Prognosis Predictor

By LabMedica International staff writers
Posted on 13 Jul 2020
Print article
Image: The Oncotype DX Genomic Prostate Score (GPS) test is a strong independent predictor of prostate cancer-specific death and disease progression (metastases) at 10 years in men with localized prostate cancer (Photo courtesy of Genomic Health).
Image: The Oncotype DX Genomic Prostate Score (GPS) test is a strong independent predictor of prostate cancer-specific death and disease progression (metastases) at 10 years in men with localized prostate cancer (Photo courtesy of Genomic Health).
Molecular assays, including multi-gene expression assays, are increasingly used clinically to improve risk stratification for men with newly diagnosed prostate cancer (PCa).

The problem for men with unfavorable intermediate (UFI)-risk PCa is that until now, the lack of definitive knowledge about this particular subtype has made it almost impossible to opt for active surveillance, despite the fact that some of them end up with less aggressive disease.

Cancer specialist at the Case Western Reserve University (Cleveland, OH, USA) and their colleagues analyzed the associations multi-gene expression assay with results with biochemical recurrence (BCR), distant metastases (DM) and prostate-specific death (PCD) in two cohorts of men with UFI prostate cancer who were treated with radical prostatectomy. The analyses included 299 intermediate-risk prostate patients, 175 of whom had UFI-risk disease; 103 from the Kaiser Permanente Northern California (KPNC) cohort and 72 from the Center for Prostate Disease Research (CDPR) cohort.

The assay used in the study was the Oncotype DX Genomic Prostate Score (GPS), (Genomic Health, Inc, Redwood City, CA, USA). The test is a quantitative reverse transcriptase polymerase chain reaction assay that measures the expression levels of 17 genes (12 cancer-related and five reference) in messenger RNA extracted from microdissected tumor tissue obtained from fixed prostate needle biopsies. It provides a GPS result scaled from 0 to 100 as a molecular measure of increasing tumor aggressiveness. It has been analytically and clinically validated as a significant independent predictor of multiple endpoints in men with newly diagnosed low and intermediate risk PCa.

The scientists reported that the GPS result as a dichotomous value (≤40 versus >40) was a significant predictor of BCR in UFI patients in multivariate analyses (hazard ratio [HR] 6.0; 95% confidence interval [CI] 2.0-22.4). The GPS result was a strong predictor of all three endpoints in multivariate analyses: BCR = HR 7.1; DM HR= 5.4; PCD HR =3.4. UFI patients with GPS >40 had outcomes consistent with high-risk disease, whereas UFI patients with GPS ≤40 had outcomes similar to FI risk patients (CPDR/KPNC).

Jennifer Cullen, PhD, MPH, an Associate Professor and the lead author of the study, said, “No one had focused specifically on unfavorable intermediate. And that's important because there is a gray zone, a very murky area, in knowing how aggressively to treat that disease, because we don't know if it's going to behave more like high-risk disease or more like favorable intermediate-risk disease. You are always trying to strike a careful balance between preserving oncologic outcome and sparing patients decrements in quality of life. So, there's this very careful discussion and balance that patients and doctors have to strike in deciding what treatment course to pursue for men in that gray zone.”

The authors concluded that the GPS result was a strong independent predictor of BCR, DM, and PCD in intermediate risk prostate cancer. UFI patients with GPS >40 have a poor prognosis and may benefit from additional therapeutic options. The study was published on June 7, 2020 in the journal Urology.

Related Links:
Case Western Reserve University
Genomic Health


Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
One Step HbA1c Measuring System
GREENCARE A1c
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
New
Gold Member
Systemic Autoimmune Testing Assay
BioPlex 2200 ANA Screen with MDSS

Print article

Channels

Clinical Chemistry

view channel
Image: Reaching speeds up to 6,000 RPM, this centrifuge forms the basis for a new type of inexpensive, POC biomedical test (Photo courtesy of Duke University)

POC Biomedical Test Spins Water Droplet Using Sound Waves for Cancer Detection

Exosomes, tiny cellular bioparticles carrying a specific set of proteins, lipids, and genetic materials, play a crucial role in cell communication and hold promise for non-invasive diagnostics.... Read more

Hematology

view channel
Image: The low-cost portable device rapidly identifies chemotherapy patients at risk of sepsis (Photo courtesy of 52North Health)

POC Finger-Prick Blood Test Determines Risk of Neutropenic Sepsis in Patients Undergoing Chemotherapy

Neutropenia, a decrease in neutrophils (a type of white blood cell crucial for fighting infections), is a frequent side effect of certain cancer treatments. This condition elevates the risk of infections,... Read more

Pathology

view channel
Image: The OvaCis Rapid Test discriminates benign from malignant epithelial ovarian cysts (Photo courtesy of INEX)

Intra-Operative POC Device Distinguishes Between Benign and Malignant Ovarian Cysts within 15 Minutes

Ovarian cysts represent a significant health issue for women globally, with up to 10% experiencing this condition at some point in their lives. These cysts form when fluid collects within a thin membrane... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.