We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




Biodegradable Nanoscaffolds Improve Chances for Stem Cell Therapies

By LabMedica International staff writers
Posted on 15 Nov 2018
Print article
Image: A biodegradable inorganic nanoscaffold consisting of stem cells, proteins, and drugs for advanced stem cell therapy and drug delivery (Photo courtesy of KiBum Lee, Letao Yang and Sy-Tsong Dean Chueng, Rutgers University).
Image: A biodegradable inorganic nanoscaffold consisting of stem cells, proteins, and drugs for advanced stem cell therapy and drug delivery (Photo courtesy of KiBum Lee, Letao Yang and Sy-Tsong Dean Chueng, Rutgers University).
The therapeutic potential of biodegradable nanoscaffolds made from manganese dioxide (MnO2) for advanced stem cell transplantation and neural tissue engineering was discussed favorably in a recent paper.

Stem cell transplantation, as a promising treatment for central nervous system diseases, has been hampered by crucial issues such as a low cell survival rate, incomplete differentiation, and limited neurite outgrowth in vivo. Inorganic and carbon-based nanoscaffolds designed to support and improve stem cell growth have been handicapped by their non-biodegradability and restricted biocompatibility, thereby delaying their wide clinical applications. On the contrary, MnO2 nanomaterials have proven to be biodegradable in other bio-applications such as cancer therapies, with MRI active Mn2+ ions as a degradation product.

Investigators at Rutgers University (New Brunswick, NJ, USA) designed nanoscaffolds that mimicked the natural tissue microenvironment to deliver physical and soluble cues. They took advantage of the biodegradability of MnO2 to incorporate its unique physiochemical properties into nano-sized structures for stem cell-based tissue engineering. The result, as described in the August 8, 2018, online edition of the journal Nature Communications was MnO2 nanomaterials-based three-dimensional hybrid nanoscaffolds that better regulated stem cell adhesion, differentiation into neurons, and neurite outgrowth in vitro and enabled enhanced stem cell transplantation benefits in vivo.

These biodegradable MnO2 nanoscaffolds could potentially serve as powerful tools for improving stem cell transplantation and advancing stem cell therapy.

"It has been a major challenge to develop a reliable therapeutic method for treating central nervous system diseases and injuries," said senior author Dr. KiBum Lee, professor of chemistry and chemical biology at Rutgers University. "Our enhanced stem cell transplantation approach is an innovative potential solution."

Related Links:
Rutgers University

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Magnetic Bead Separation Modules
MAG and HEATMAG
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
New
Gold Member
Magnetic Bead Separation Modules
MAG and HEATMAG

Print article

Channels

Clinical Chemistry

view channel
Image: The 3D printed miniature ionizer is a key component of a mass spectrometer (Photo courtesy of MIT)

3D Printed Point-Of-Care Mass Spectrometer Outperforms State-Of-The-Art Models

Mass spectrometry is a precise technique for identifying the chemical components of a sample and has significant potential for monitoring chronic illness health states, such as measuring hormone levels... Read more

Hematology

view channel
Image: The CAPILLARYS 3 DBS devices have received U.S. FDA 510(k) clearance (Photo courtesy of Sebia)

Next Generation Instrument Screens for Hemoglobin Disorders in Newborns

Hemoglobinopathies, the most widespread inherited conditions globally, affect about 7% of the population as carriers, with 2.7% of newborns being born with these conditions. The spectrum of clinical manifestations... Read more

Immunology

view channel
Image: A false color scanning election micrograph of lung cancer cells grown in culture (Photo courtesy of Anne Weston)

AI Tool Precisely Matches Cancer Drugs to Patients Using Information from Each Tumor Cell

Current strategies for matching cancer patients with specific treatments often depend on bulk sequencing of tumor DNA and RNA, which provides an average profile from all cells within a tumor sample.... Read more

Microbiology

view channel
Image: Microscope image showing human colorectal cancer tumor with Fusobacterium nucleatum stained in a red-purple color (Photo courtesy of Fred Hutch Cancer Center)

Mouth Bacteria Test Could Predict Colon Cancer Progression

Colon cancer, a relatively common but challenging disease to diagnose, requires confirmation through a colonoscopy or surgery. Recently, there has been a worrying increase in colon cancer rates among younger... Read more

Pathology

view channel
Image: Fingertip blood sample collection on the Babson Handwarmer (Photo courtesy of Babson Diagnostics)

Unique Hand-Warming Technology Supports High-Quality Fingertip Blood Sample Collection

Warming the hand is an effective way to facilitate blood collection from a fingertip, yet off-the-shelf solutions often do not fulfill laboratory requirements. Now, a unique hand-warming technology has... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.