We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




Events

09 Apr 2024 - 12 Apr 2024
15 Apr 2024 - 17 Apr 2024
23 Apr 2024 - 26 Apr 2024

Genetic Alterations Correlated to Aggressive Prostate Cancer

By LabMedica International staff writers
Posted on 03 Aug 2018
Print article
Image: A histopathology of adenoid cystic/basal cell carcinoma of the prostate gland (Photo courtesy of Nephron).
Image: A histopathology of adenoid cystic/basal cell carcinoma of the prostate gland (Photo courtesy of Nephron).
Prostate cancer is the second most common cancer among men, and while the disease is often indolent and treatable, some cases are aggressive. Distinguishing between the two could guide treatment decisions.

About 80% of the time prostate cancer cells metastasize, or spread, they will spread to bones, such as the hip, spine and pelvis bones. It can be by direct invasion or by traveling through the blood or lymphatic system. Prostate cancer with local spread has a 5-year survival rate at nearly 100%. Prostate cancer with distant metastasis has a 5-year survival rate of around 29%.

An international team of scientists led by those at the University of Oulu (Oulu, Finland) have confirmed in their new analysis of nearly 3,000 Finnish prostate cancer cases, that previous genome-wide association studies (GWAS) that identified rs11672691 at 19q13 is associated with aggressive prostate cancer (PCa). They conducted an expression quantitative trait locus analysis in three independent cohorts and found that the risk allele is linked to the expression levels of both CEACAM21 and PCAT19.

The team used knockdown, overexpression, and other assays, and found that not only are CEACAM21 and PCAT19 highly expressed in prostate cancer tissue as compared to control tissues, but also that knocking them down in prostate cancer cell lines is associated with decreased cell proliferation, migration, and invasion. The risk allele falls within an enhancer element and changes the binding site of HOXA2, which is itself an oncogene associated with poor prognosis. This suggested to them that the risk allele works with HOXA2 to drive CEACAM21 and PCAT19 expression. CRISPR/Cas9-mediated single-nucleotide editing showed the direct effect of rs11672691 on PCAT19 and CEACAM21 expression and PCa cellular aggressive phenotype.

The authors concluded that their findings may allow better prognostic prediction and distinguishing a more lethal phenotype to identify high-risk group patients that need radical treatment regimens because of their poorer treatment outcomes. These results provide a plausible mechanism for rs11672691 associated with aggressive PCa and thus lay the ground work for translating this finding to the clinic. The study was published on June 28, 2018, in the journal Cell.

Related Links:
University of Oulu

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
One Step HbA1c Measuring System
GREENCARE A1c
Complement 3 (C3) Test
GPP-100 C3 Kit
New
Gold Member
Plasma Control
Plasma Control Level 1

Print article

Channels

Clinical Chemistry

view channel
Image: Reaching speeds up to 6,000 RPM, this centrifuge forms the basis for a new type of inexpensive, POC biomedical test (Photo courtesy of Duke University)

POC Biomedical Test Spins Water Droplet Using Sound Waves for Cancer Detection

Exosomes, tiny cellular bioparticles carrying a specific set of proteins, lipids, and genetic materials, play a crucial role in cell communication and hold promise for non-invasive diagnostics.... Read more

Hematology

view channel
Image: The low-cost portable device rapidly identifies chemotherapy patients at risk of sepsis (Photo courtesy of 52North Health)

POC Finger-Prick Blood Test Determines Risk of Neutropenic Sepsis in Patients Undergoing Chemotherapy

Neutropenia, a decrease in neutrophils (a type of white blood cell crucial for fighting infections), is a frequent side effect of certain cancer treatments. This condition elevates the risk of infections,... Read more

Pathology

view channel
Image: The OvaCis Rapid Test discriminates benign from malignant epithelial ovarian cysts (Photo courtesy of INEX)

Intra-Operative POC Device Distinguishes Between Benign and Malignant Ovarian Cysts within 15 Minutes

Ovarian cysts represent a significant health issue for women globally, with up to 10% experiencing this condition at some point in their lives. These cysts form when fluid collects within a thin membrane... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.