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评估丙肝病毒的快速床旁检验

By LabMedica International staff writers
Posted on 19 Apr 2018
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Xpert丙肝(HCV)病毒载量测定盒(图片蒙Cepheid公司惠赐)。
Xpert丙肝(HCV)病毒载量测定盒(图片蒙Cepheid公司惠赐)。
现行的丙肝(HCV)检验包括两次门诊。初诊时,临床医师检查丙肝病毒抗体,这只能证明病人接触过病毒。复诊时检验HCV RNA,以确定存在活跃感染。
 
床旁丙肝病毒(HCV) RNA检验有利于在单次门诊时诊断活跃感染。此前的研究显示,病人在随访中流失,因为他们不回来复诊,如果没有抽血师,该过程就难以进行,对于注射药物(PWID)者,静脉可能难以下手,增加了检查难度。
 
澳大利亚悉尼新南威尔士大学的科学家及其同事从2016年8月3日至2016年12月13日期间在澳大利亚的三家药疗诊所及一所无家可归者服务站招募参与者。共招募了223人参与研究,72%的人有使用注射药物的历史,46%的人在参与研究的前一个月注射过药物。
 
研究人员评估了美国加利福尼亚州森尼韦尔市Cepheid公司的指血Xpert HCV病毒载量测定(Xpert HCV VL FS)与血浆Xpert HCV病毒载量测定检测HCV RNA的灵敏度与特异性,并与雅培实验室(Abbott Park, IL, USA; 的静脉穿刺实时HCV病毒载量测定进行比较。
 
该研究的论文发表于2018年3月9日的《传染病杂志》(The Journal of Infectious Diseases)。作者发现,招募的223名参与者中,接受过Xpert HCV病毒载量检验的人中40%的人(210人中的85人)体内检测到HCV RNA。后续分析不包括接受过HCV疗法的参与者。通过静脉穿刺采集血浆,Xpert HCV病毒载量测定量化血浆中HCV RNA的灵敏度为100%,特异性为100%。通过针刺指尖采集血样,Xpert HCV VL FS测定量化HCV RNA的灵敏度为100%,特异性也是100%。
 
作者总结说,这项检验相较基于抗体的床旁检验取得了重大进步,后者只能指示接触过HCV。再者,新型Xpert VL FS测定相较现有的Xpert HCV病毒载量测定取得巨大进步,无需分离血浆,检验和诊断时间从两小时缩短到一小时,更有希望实现通过一次门诊诊断。
 
Related Links:

新南威尔士大学>>> www.unsw.edu.au

Cepheid >>> www.cepheid.com

雅培实验室>>> www.molecular.abbott


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