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通过血检预测肺癌患者的治疗效果

By LabMedica International staff writers
Posted on 10 Nov 2017
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图片:cobas EGFR突变检验v2 CE-IVD能识别非小细胞肺癌(NSCLC)患者DNA里的表皮生长因子受体(EGFR)基因(图片蒙罗氏分子诊断公司惠赐)。
图片:cobas EGFR突变检验v2 CE-IVD能识别非小细胞肺癌(NSCLC)患者DNA里的表皮生长因子受体(EGFR)基因(图片蒙罗氏分子诊断公司惠赐)。
诊断肺癌的传统方法仅依靠肺活组织检查,它是一种创伤性手术,许多患者难以忍受。一项简易血检能用血样检测肿瘤DNA里的基因突变,且诊断速度更快,更多享受到救命药,从而让肺癌患者有了新选择。

2014年,肺癌是英国的第三大常见癌症,英国剑桥癌症研究所的最新统计数据显示,有46,400例肺癌新病例。这项新检验为靶向表皮生长因子受体(EGFR)异常的分子疗法严格把关,快速识别适于靶向疗法的患者,使他们避免化疗及其副作用。

英国NHS信托基金会下属的伯明翰大学医院(UH)将该检验引入其著名的癌症诊断实验室。新的化验服务让更多患者享受到救命的治疗,且副作用小于传统化疗,从而改善了患者的生活质量。该检验特异性强,结果可用来预测病人对治疗的反应,让医生能够快速制定个性化治疗方案,且方案符合英格兰NHS的目标——确保个性化治疗及医治每个诊断出癌症的人。

美国加利福尼亚州普莱森顿市罗氏分子诊断公司)的cobas EGFR突变检验v2 CE-IVD能识别非小细胞肺癌(NSCLC)患者DNA里的表皮生长因子受体(EGFR)基因,旨在辅助选出适于EGFR酪氨酸激酶抑制剂(TKI)疗法的NSCLC患者。这款创新性测定产品第一次用血浆作为除组织外的另一种样本类型,因而消除了分子检验的常见障碍,包括手术风险和是否可得到样本。该检验的结果清晰、实用,能为临床医师做出可信的治疗决策提供信息。

cobas EGFR突变检验v2 CE-IVD的报表中有一项新特征,称为半量化指标(SQI)。这个数值的设计目的是表示样本里突变的百分比。如果用该产品频繁检验EGFR突变,追踪SQI值并找出趋势,也许就能理解肿瘤的进展,而其它检验产品还不具备这一功能。

UHB的组织病理医师Phillipe Taniere博士说:“识别血样里的突变一直是个难题,因为样本里发现癌细胞的频率很低。然而,罗氏诊断公司的这项强大的新技术有可能取一份简单的血样就能发现肿瘤DNA里的EGFR突变。”

Related Links:
NHS信托基金会下属伯明翰大学医院
罗氏分子诊断公司


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