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Oncolab公司在AACC上展出领先的AMAS癌症检验

By LabMedica International staff writers
Posted on 04 Sep 2014
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图片:AMAS检验是一种癌症诊断检验,它测量血液循环中抗体的水平,因为几乎所有类型的癌症都会使抗体水平升高(图片蒙Oncolab公司惠赐)。
图片:AMAS检验是一种癌症诊断检验,它测量血液循环中抗体的水平,因为几乎所有类型的癌症都会使抗体水平升高(图片蒙Oncolab公司惠赐)。
美国马萨诸塞州波士顿的Oncolab公司在实验室开发的AMAS癌症检验在今年的AACC 2014大会上完成了AACC首秀。该检验是基于血清的体外免疫测定,迄今为止已在6万多名患者身上用过,作为检测工具在对抗癌症复发战斗中崭露头角。

据估计仅美国就有1700万癌症幸存者,人们竞相开发更好的技术来识别癌症是否已开始复发,如果复发,其发展速度如何。一个明显的趋势是用免疫测定进行癌症诊断,用免疫疗法进行治疗。AMAS检验测量特定抗体——抗致恶性素抗体——的水平,因而符合上述趋势;人们认为这种抗体是机体的免疫系统为应对几乎所有类型的癌症而产生的。

大多数其它癌症免疫测定测量血液循环中的癌症抗原,但癌症抗原水平的升高晚于AMAS检验测得抗体的时机。因此,AMAS检验有助于在早期抗致恶性素抗体水平升高时发现癌症复发的迹象。这样的性能不同寻常——假阳性和假阴性率都不到10%。虽然AMAS检验确实能引导医生发现癌症的可能位置,但新型高分辨率成像技术、更多针对位置的癌症检验和临床迹象都能帮助临床医师掌握更详实的病情。

目前,Oncolab公司通过其CLIA认证的实验室提供这项检验服务,实验室位于波士顿。血清样本必须连夜运送,Oncolab公司免费提供运输专用的标准化容器和试管,抽血时从实验室获得干冰,并分离成血清。该检验产品获得了美国食品药品管理局(FDA; www.fda.gov)批准,由医保报销。

今天,大多数样本是从美国和加拿大抽取的;海外的化验室也可以发送样本,Oncolab公司敦促他们联系Oncolab公司,建立技术和商业上的合作关系。

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