We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




Events

09 Apr 2024 - 12 Apr 2024
15 Apr 2024 - 17 Apr 2024
23 Apr 2024 - 26 Apr 2024

Multiple Sclerosis Detected by Analysis of Exhaled Breath

By LabMedica International staff writers
Posted on 23 Aug 2012
Print article
A sensor array has been developed that can diagnose multiple sclerosis (MS) from exhaled breath.

Scientists identified volatile organic compounds from exhaled breath that can be associated with MS. Based on these findings they developed a sensor array that can diagnose MS by analyzing the compounds that appear in the breath of MS patients. The cross-reactive array of polycyclic aromatic hydrocarbons and single wall carbon-nanotube bilayers were designed for the detection of volatile organic compounds (hexanal and 5-methyl-undecane) that identify the presence of disease in the exhaled breath of patients with MS.

Using the sensors, the scientists carried out a proof-of-concept clinical study on 34 MS patients and 17 healthy volunteers and found that the developed sensors are just as accurate as a lumbar puncture but without the pain or the risk of side effects. Results obtained from the study showed that the sensors could discriminate between MS and healthy states from exhaled breath samples with 85.3% sensitivity, 70.6% specificity, and 80.4% accuracy.

Initiator and coordinator of the study, Prof. Hossam Haick at the department of chemical engineering and Russell Berrie Nanotechnology Institute, Technion–Israel Institute of Technology (Haifa, Israel) and colleagues report that doctors currently diagnose MS according to clinical symptoms, which include muscle spasms, numbness, coordination problems, and slurred speech. Confirmation of the diagnosis is made by either magnetic resonance imaging (MRI), which is costly, or lumbar puncture, which is invasive and can be painful with unpleasant side effects.


The study was published in the journal ACS Chemical Neuroscience in 2012.

Related Links:

Technion–Israel Institute of Technology



Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
One Step HbA1c Measuring System
GREENCARE A1c
POCT Fluorescent Immunoassay Analyzer
FIA Go
New
Gold Member
Systemic Autoimmune Testing Assay
BioPlex 2200 ANA Screen with MDSS

Print article

Channels

Molecular Diagnostics

view channel
Image: The cobas Malaria test is the first FDA-approved molecular test to screen U.S. blood donors for malaria (Photo courtesy of Roche)

First FDA-Approved Molecular Test to Screen Blood Donors for Malaria Could Improve Patient Safety

Malaria, a serious illness that often leads to death, is spread by a specific mosquito species that infect humans with a parasite. Other transmission modes include blood transfusions, organ transplants,... Read more

Hematology

view channel
Image: The low-cost portable device rapidly identifies chemotherapy patients at risk of sepsis (Photo courtesy of 52North Health)

POC Finger-Prick Blood Test Determines Risk of Neutropenic Sepsis in Patients Undergoing Chemotherapy

Neutropenia, a decrease in neutrophils (a type of white blood cell crucial for fighting infections), is a frequent side effect of certain cancer treatments. This condition elevates the risk of infections,... Read more

Pathology

view channel
Image: The medical office procedure detects the key biomarker in Parkinson’s and related neurodegenerative diseases (Photo courtesy of BIDMC)

Simple Skin Biopsy Test Detects Parkinson’s and Related Neurodegenerative Diseases

Parkinson's disease and a group of related neurodegenerative disorders known as synucleinopathies impact millions globally. These conditions, including Parkinson’s disease (PD), dementia with Lewy bodies... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.