We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
PURITAN MEDICAL

Luminex Corporation

Luminex develops, manufactures, and markets biological testing technologies with applications in clinical diagnostics... read more Featured Products: More products

Download Mobile App




Events

09 Apr 2024 - 12 Apr 2024
15 Apr 2024 - 17 Apr 2024
23 Apr 2024 - 26 Apr 2024

Protein Biomarkers Identified for Dysglycemia Cardiovascular Risk

By LabMedica International staff writers
Posted on 01 Dec 2015
Print article
The Luminex 200 Multiplexing System
The Luminex 200 Multiplexing System (Photo courtesy of Luminex - A Diasorin Company)
Impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes independently increase the risk of cardiovascular (CV) outcomes, and diabetes reduces life expectancy by up to 15 years.

Despite recent reductions in the incidence of CV outcomes in people with diabetes, both diabetes and lesser degrees of dysglycemia remain independent CV risk factor. The pathophysiologic reasons for this excess and for variations in incidence among people who already have established dysglycemia remain unclear.

A team of scientists working with a group at the Hamilton General Hospital (Hamilton, ON, Canada) recruited from a trial 12,537 people with either diabetes, impaired glucose tolerance or impaired fasting glucose and additional CV risk factors and followed for a median of 6.2 years. A subset of 8,494 (68%) also provided written consent for the collection and storage of a blood sample for future measurement of CV risk factors. Baseline fasting samples were collected, spun, separated ̧ and divided into 1.5-2.0 mL aliquots.

The team used a customized Human Discovery Multi-Analyte Profile 250+ panel on the LUMINEX 100/200platforms (Luminex; Austin, TX, USA). The DiscoveryMAP platform (Myriad RBM Inc.; Austin, TX, USA) measured a panel of 284 biomarkers in a serum sample from each participant. The panel included a combination of assays that had already been developed plus additional biomarker assays that were newly developed for the study.

The DiscoveryMAP platform successfully identified combinations of 15 protein biomarkers associated with cardiovascular (CV) events or death in people with pre-diabetes or early type 2 diabetes. After forcing in the clinical risk factors, 8 out of a possible 237 biomarkers each independently improved the ability to predict the CV composite outcome. Three of these eight biomarkers plus an additional four, a total of seven, were identified when the process was repeated for the expanded CV composite outcome. Three biomarkers, N-terminal of the prohormone brain natriuretic peptide (NT-proBNP), angiopoietin 2 and gluthathione S transferase alpha, were persistently identified in all models and for all outcomes.

Hertzel Gerstein, MD, the lead study investigator, said, “Our study is one of the largest scientific investigations in history to identify specific cardiovascular biomarkers associated with serious cardiovascular outcomes, including heart attacks, strokes and death. Our results highlight the potential value of cardiovascular biomarkers for identifying people with dysglycemia at the highest risk of future events.” The study was published on October 30, 2015, in the journal Circulation.

Related Links:

Hamilton General Hospital 
Luminex
Myriad RBM Inc. 


Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
One Step HbA1c Measuring System
GREENCARE A1c
Complement 3 (C3) Test
GPP-100 C3 Kit
New
Gold Member
Systemic Autoimmune Testing Assay
BioPlex 2200 ANA Screen with MDSS
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get complete access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Molecular Diagnostics

view channel
Image: MOF materials efficiently enrich cfDNA and cfRNA in blood through simple operational process (Photo courtesy of Science China Press)

Blood Circulating Nucleic Acid Enrichment Technique Enables Non-Invasive Liver Cancer Diagnosis

The ability to diagnose diseases early can significantly enhance the effectiveness of clinical treatments and improve survival rates. One promising approach for non-invasive early diagnosis is the use... Read more

Hematology

view channel
Image: The low-cost portable device rapidly identifies chemotherapy patients at risk of sepsis (Photo courtesy of 52North Health)

POC Finger-Prick Blood Test Determines Risk of Neutropenic Sepsis in Patients Undergoing Chemotherapy

Neutropenia, a decrease in neutrophils (a type of white blood cell crucial for fighting infections), is a frequent side effect of certain cancer treatments. This condition elevates the risk of infections,... Read more

Pathology

view channel
Image: The OvaCis Rapid Test discriminates benign from malignant epithelial ovarian cysts (Photo courtesy of INEX)

Intra-Operative POC Device Distinguishes Between Benign and Malignant Ovarian Cysts within 15 Minutes

Ovarian cysts represent a significant health issue for women globally, with up to 10% experiencing this condition at some point in their lives. These cysts form when fluid collects within a thin membrane... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.