We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
INTEGRA BIOSCIENCES AG

Download Mobile App




Events

09 Apr 2024 - 12 Apr 2024
15 Apr 2024 - 17 Apr 2024
23 Apr 2024 - 26 Apr 2024

Oral HPVs Associated with Risk of Incident Head and Neck Cancers

By LabMedica International staff writers
Posted on 31 Jan 2016
Print article
Image: Human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) identified by in situ hybridization (Photo courtesy of Jennifer L. Hunt, MD, and Wikimedia).
Image: Human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) identified by in situ hybridization (Photo courtesy of Jennifer L. Hunt, MD, and Wikimedia).
A prospective study suggests that detection in the oral cavity of certain human papillomavirus (HPV) types is associated with higher risk of incident head and neck squamous cell carcinoma (HNSCC), suggesting that the role of HPV in HNSCC may be even more important than currently recognized.

The oral cavity contains a wide spectrum of α-, β-, and γ-HPV types, but their association with risk of HNSCC (which includes cancers of the oropharynx, oral cavity, and larynx) is unknown. Ilir Agalliu, MD, ScD, of Albert Einstein College of Medicine (Bronx, NY, USA) and colleagues tested mouthwash samples from study participants using next-generation sequencing to detect DNA from α-, β-, and γ-HPV types. Results were adjusted for smoking history, alcohol consumption, and detection of HPV-16 for β- and γ-HPVs.

The researchers found that detection of HPV-16 in the oral cavity was associated with 22-times increased risk of oropharyngeal squamous cell carcinoma, demonstrating that HPV-16 detection precedes the incidence of oropharyngeal SCC. They also found that positive associations with HNSCC risk for other oral HPVs usually detected on the skin suggest a broader role for HPVs in HNSCC etiology.

The study was carried out among 96,650 participants from 2 large prospective cohort groups who were cancer-free at baseline and had available mouthwash samples. There were 132 cases of HNSCC identified during an average follow-up of almost 4 years, and 396 healthy individuals (3 per case of HNSCC). The authors noted limitations of the study due to small sample size, which reflects the rarity of HNSCC.

“The use of easily collected oral mouthwash samples can provide a prospective marker for risk of HNSCC and oropharyngeal SCC,” the study concludes.

The study, by Agalliu I et al., was published online ahead of print January 21, 2016, in the journal JAMA Oncology.

Related Links:

Albert Einstein College of Medicine

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
One Step HbA1c Measuring System
GREENCARE A1c
POCT Fluorescent Immunoassay Analyzer
FIA Go
Gold Member
Xylazine Immunoassay Test
Xylazine ELISA

Print article

Channels

Clinical Chemistry

view channel
Image: Reaching speeds up to 6,000 RPM, this centrifuge forms the basis for a new type of inexpensive, POC biomedical test (Photo courtesy of Duke University)

POC Biomedical Test Spins Water Droplet Using Sound Waves for Cancer Detection

Exosomes, tiny cellular bioparticles carrying a specific set of proteins, lipids, and genetic materials, play a crucial role in cell communication and hold promise for non-invasive diagnostics.... Read more

Hematology

view channel
Image: The low-cost portable device rapidly identifies chemotherapy patients at risk of sepsis (Photo courtesy of 52North Health)

POC Finger-Prick Blood Test Determines Risk of Neutropenic Sepsis in Patients Undergoing Chemotherapy

Neutropenia, a decrease in neutrophils (a type of white blood cell crucial for fighting infections), is a frequent side effect of certain cancer treatments. This condition elevates the risk of infections,... Read more

Pathology

view channel
Image: The OvaCis Rapid Test discriminates benign from malignant epithelial ovarian cysts (Photo courtesy of INEX)

Intra-Operative POC Device Distinguishes Between Benign and Malignant Ovarian Cysts within 15 Minutes

Ovarian cysts represent a significant health issue for women globally, with up to 10% experiencing this condition at some point in their lives. These cysts form when fluid collects within a thin membrane... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.