Features | Partner Sites | Information | LinkXpress
Sign In
SIEMENS DIAGNOSTICS

Enzyme Linked to Aggressive Prostate Cancer

By Labmedica International staff writers
Posted on 17 Jan 2013
The enzyme mesotrypsin, also known as protease, serine 3 (PRSS3), is specifically associated with aggressive prostate cancer risk.

Mesotrypsin appears to be an important mediator of prostate cancer progression and metastasis, and it has been suggested that inhibition of mesotrypsin activity may provide a novel modality for prostate cancer treatment.

Cancer biologists at the Mayo Clinic (Jacksonville, Florida, USA) explored whether any other cancer abnormally expresses the enzyme PRSS3 and when this occurred. They gathered and analyzed data from several sources. They used various techniques including cell culture, ribonucleic acid (RNA) extraction and polymerase chain reaction (PCR), bioluminescent imaging, and immunohistochemistry.

By transcriptional profiling, the investigators identified a correlation between PRSS3 gene expression and prostate cancer progression in a microarray dataset in which five benign prostate, five clinically localized prostate cancer, and five metastatic prostate cancer tissue specimens. They found that PRSS3 expression in tumors was strikingly associated with recurrence, defined as systemic progression or rising prostate specific antigen. The association of PRSS3 with prostate cancer metastasis, and the evidence that PRSS3 expression in primary tumors is prognostic of recurrence, suggest that mesotrypsin may play a critical functional role in prostate cancer progression.


Evette Radisky, PhD, the senior investigator, said, "This molecule is a protease, which means it digests other molecules. Our data suggests PRSS3 activity changes the environment around prostate cancer cells, perhaps by freeing them from surrounding tissue to promote malignancy and invasiveness. I do not think PRSS3 is the only factor involved in driving aggressive prostate cancer, but it may be significant for a certain subset of this cancer, the kind that is potentially lethal. Prostate cancer patients could be tested for the presence of the enzyme, so that doctors could identify which ones had the highest risk of metastasis." The study was published on December 17, 2012, in the journal Molecular Cancer Research.

Related Links:

Mayo Clinic



comments powered by Disqus

Channels

Clinical Chemistry

view channel
Image:  The Agilent 6890 GC with 5973 Mass Spectrometer and Tekmar Velocity XPT Purge & Trap (Photo courtesy of Gen Tech).

Low Levels of Prohormone Predicts Coronary Heart Disease

The adrenal sex hormone dehydroepiandrosterone (DHEA), which is present in serum mainly as the sulfate DHEA-S, is the most abundant steroid hormone in human blood and its levels decline dramatically with age.... Read more

Microbiology

view channel
Image: The causative parasite of Chagas disease Trypanosoma cruzi in a blood film (Photo courtesy of the CDC - US Centers for Disease Control and Prevention).

Undiagnosed Chagas Disease Emerging as Public Health Threat

Chagas disease or American trypanosomiasis is typically spread to people through the feces of blood-sucking triatomine bugs sometimes called kissing bugs because they feed on people's faces during the night.... Read more

Industry News

view channel

Oncology Companion Diagnostics Sector Grows to Over USD 1 Billion

The market for diagnostic test and pharmaceutical drug pairs for cancer treatment has grown significantly, according to the report “Companion Diagnostic Markets” from healthcare market research firm Kalorama Information (New York City, NY, USA). The global companion diagnostics (CDx) market is valued at about USD 1.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.