Features | Partner Sites | Information | LinkXpress
Sign In
FOCUS DIAGNOSTICS, INC.
GLOBETECH PUBLISHING
RANDOX LABORATORIES

Many Healthy Adults Infected with Human Papilloma Viruses

By Labmedica International staff writers
Posted on 05 Jun 2014
Image: Scanning electron micrograph of human papillomavirus (HPV) (Photo courtesy of University of Washington).
Image: Scanning electron micrograph of human papillomavirus (HPV) (Photo courtesy of University of Washington).
The largest and most detailed genetic analysis has revealed that 69% of healthy American adults are infected with one or more of 109 strains of human papillomavirus (HPV).

While most of the viral strains so far appear to be harmless and can remain dormant for years, their overwhelming presence suggests a delicate balancing act for HPV infection in the body, in which many viral strains keep each other in check, preventing other strains from spreading out of control.

Scientists at the New York University (NYU) Langone Medical Center (NY, USA) analyzed data made publicly available from the US National Institutes of Health (NIH, Bethesda MD, USA) Human Microbiome Project, which is gathering information on microorganisms' effects on human health. The NIH data consisted of comprehensive DNA analyses assembled by a technique called shotgun sequencing. The DNA decoding technique helped sort through vast amounts of genetic material among 748 tissue swabs of study participants' major organs, including skin, vagina, mouth, and gut. Tissue samples were originally collected from healthy study volunteers, ages 18 to 80, participating in the NIH project. In shotgun sequencing, the genetic code of long strands of DNA is deciphered in a random firing pattern.

Some of the key findings were that 109 of 148 known HPV types were detected in study participants. Most study participants had HPV infections: 61% in the skin; 41% in the vagina, 30% in the mouth, and 17% in the gut. Of the 71 study participants infected with HPV, 42 (59%) had HPV in only one organ, 22 (31%) had it in two organs, and seven (10%) had it in three; none had HPV in all four organs tested. Skin samples contained the most varied HPV strains with 80 types of HPV, including 40 that were found only in the skin. Vaginal tissue had the second most numerous strains 43 types of HPV, with 20 strains exclusive to the organ.

In mouth tissue there were 33 types, of which five were exclusively oral in origin, and six types were found in gut tissue, all of which were found in other organs.

Zhiheng Pei, MD, PhD, the senior investigator, said, “The results also highlight the weaknesses in current clinical test kits for HPV, currently designed to recognize only a dozen or more viral types most closely tied to cervical cancer. Broader detection methods and comprehensive diagnostic tests are needed to more accurately assess people's "true" HPV infection status.” The study was presented at the annual meeting of the American Society for Microbiology on May 20, 2014, in Boston (MA, USA).

Related Links:

New York University Langone Medical Center 
US National Institutes of Health 



EUROIMMUN AG
PURITAN MEDICAL
Sekisui Diagnostics
comments powered by Disqus
Life Technologies

Channels

Clinical Chemistry

view channel
Image: Enzyme-linked immunosorbent kit (ELISA) specific for human copeptin (Photo courtesy of USCN Life Science).

Preeclampsia Biomarker Detected Very Early In Pregnancy

A biomarker has been discovered that could give expecting mothers and their doctors the first simple blood test to reliably predict that a pregnant woman may develop preeclampsia, at least as early as... Read more

Pathology

view channel
Image: Glioblastoma multiforme (GBM) (Photo courtesy of the University of California, San Diego School of Medicine).

Brain Tumor Chemotherapy Biomarkers Identified

Cancer researchers have identified a new biomarker that they believe can predict whether glioblastoma multiformes (GBMs), the most common and aggressive type of malignant brain tumor, will be susceptible... Read more

Lab Tech.

view channel
Image:  The Becton Dickinson fluorescent activated cell sorter FACScan (Photo courtesy of the Albert Einstein College of Medicine).

Noninvasive Method Captures Circulating Tumor Cells

A clinically proven, noninvasive fluorescence virus-guided capture system of human colorectal circulating tumor cells (CTCs) from blood samples for genetic testing has been introduced. This noninvasive... Read more

Industry News

view channel

Beckman Coulter Acquires Siemens Healthcare Diagnostics’ Clinical Microbiology Business

Beckman Coulter (Brea, CA, USA), an indirect wholly-owned subsidiary of Danaher Corp. (Washington DC, MD, USA) has entered into a definitive agreement to purchase the clinical microbiology business of Siemens Healthcare Diagnostics (Chicago, IL, USA). The transaction is expected to close in the first quarter of 2015.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.