Features | Partner Sites | Information | LinkXpress
Sign In
FOCUS DIAGNOSTICS, INC.
AB Sciex
Bio-Rad Diabetes Division

STD Bacteria Leads to Potential HIV Infection

By Labmedica International staff writers
Posted on 29 Mar 2012
African women who are infected with a common sexually transmitted bacterial infection are two times more likely to acquire Human immunodeficiency virus (HIV) infection.

Mycoplasma genitalium is an emerging sexually transmitted infection (STI) associated with reproductive tract syndromes in men causing urethritis, and in women, it is associated with cervicitis and pelvic inflammatory disease.

In a multi-institute study, conducted by the Research Triangle Institute (RTI International; San Francisco, CA, USA) HIV-negative women from Zimbabwe and Uganda were tested once every 12 weeks for a median of 22 months. Blood was collected for HIV diagnosis using several different enzyme-linked immunosorbent assays (ELISA). M. genitalium testing was performed on samples at the HIV detection visit and the last HIV-negative visit for cases, and equivalent visits in follow-up time for controls. Presence of M. genitalium DNA was assessed by in-house polymerase chain reaction (PCR)-ELISA, using the archived cervical swab samples, which had been stored at -20 °C.

The scientists compared 190 women who became infected with HIV during follow-up to women of a comparable age and risk who were not infected with HIV. The team examined women in both groups for the presence of M. genitalium, which was assessed as a risk factor for HIV infection. They found that in initial samples when all participants were HIV free, approximately 15% of women who later developed HIV were infected with M. genitalium compared with 6.5% in women who did not develop the disease. Furthermore, the team found that M. genitalium was more prevalent that other bacterial sexually transmitted diseases caused by Neisseria gonorrhoeae and Chlamydia trachomatis.

According to the team, M. genitalium was responsible for approximately 9% of all HIV infections occurring in the study. Other factors, such as having a partner with HIV risk factors, or the presence of herpes simplex virus 2, which causes genital herpes, were more strongly linked to HIV risk. Sue Napierala Mavedzenge, PhD, a lead researcher of the study, said, "Further research will be required to confirm a causal relationship and to identify risk factors for M. genitalium infection in African populations. If findings from this research are confirmed, M. genitalium screening and treatment among women at high risk for HIV-1 infection may be warranted as part of an HIV-1 prevention strategy.” The study was published March 13, 2012 in the journal AIDS.

Related Links:

Research Triangle Institute



77 ELEKTRONIKA
DiagCor Bioscience
PURITAN MEDICAL
comments powered by Disqus
Life Technologies

Channels

Clinical Chemistry

view channel
Image:  The Agilent 6890 GC with 5973 Mass Spectrometer and Tekmar Velocity XPT Purge & Trap (Photo courtesy of Gen Tech).

Low Levels of Prohormone Predicts Coronary Heart Disease

The adrenal sex hormone dehydroepiandrosterone (DHEA), which is present in serum mainly as the sulfate DHEA-S, is the most abundant steroid hormone in human blood and its levels decline dramatically with age.... Read more

Pathology

view channel
Image: The Isolation by Size of Epithelial Tumor cells (ISET) technology (Photo courtesy of Rarecells Diagnostics).

Circulating Tumor Cells Allow Early Diagnosis of Lung Cancer

Chronic obstructive pulmonary disease (COPD) is a risk factor for lung cancer and migration of circulating tumor cells (CTCs) into the blood stream is an early event that occurs during carcinogenesis.... Read more

Industry News

view channel

Oncology Companion Diagnostics Sector Grows to Over USD 1 Billion

The market for diagnostic test and pharmaceutical drug pairs for cancer treatment has grown significantly, according to the report “Companion Diagnostic Markets” from healthcare market research firm Kalorama Information (New York City, NY, USA). The global companion diagnostics (CDx) market is valued at about USD 1.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.