Features | Partner Sites | Information | LinkXpress
Sign In
FOCUS DIAGNOSTICS, INC.
Biostrata Ltd on behalf of Thermo
RANDOX LABORATORIES

STD Bacteria Leads to Potential HIV Infection

By Labmedica International staff writers
Posted on 29 Mar 2012
African women who are infected with a common sexually transmitted bacterial infection are two times more likely to acquire Human immunodeficiency virus (HIV) infection.

Mycoplasma genitalium is an emerging sexually transmitted infection (STI) associated with reproductive tract syndromes in men causing urethritis, and in women, it is associated with cervicitis and pelvic inflammatory disease.

In a multi-institute study, conducted by the Research Triangle Institute (RTI International; San Francisco, CA, USA) HIV-negative women from Zimbabwe and Uganda were tested once every 12 weeks for a median of 22 months. Blood was collected for HIV diagnosis using several different enzyme-linked immunosorbent assays (ELISA). M. genitalium testing was performed on samples at the HIV detection visit and the last HIV-negative visit for cases, and equivalent visits in follow-up time for controls. Presence of M. genitalium DNA was assessed by in-house polymerase chain reaction (PCR)-ELISA, using the archived cervical swab samples, which had been stored at -20 °C.

The scientists compared 190 women who became infected with HIV during follow-up to women of a comparable age and risk who were not infected with HIV. The team examined women in both groups for the presence of M. genitalium, which was assessed as a risk factor for HIV infection. They found that in initial samples when all participants were HIV free, approximately 15% of women who later developed HIV were infected with M. genitalium compared with 6.5% in women who did not develop the disease. Furthermore, the team found that M. genitalium was more prevalent that other bacterial sexually transmitted diseases caused by Neisseria gonorrhoeae and Chlamydia trachomatis.

According to the team, M. genitalium was responsible for approximately 9% of all HIV infections occurring in the study. Other factors, such as having a partner with HIV risk factors, or the presence of herpes simplex virus 2, which causes genital herpes, were more strongly linked to HIV risk. Sue Napierala Mavedzenge, PhD, a lead researcher of the study, said, "Further research will be required to confirm a causal relationship and to identify risk factors for M. genitalium infection in African populations. If findings from this research are confirmed, M. genitalium screening and treatment among women at high risk for HIV-1 infection may be warranted as part of an HIV-1 prevention strategy.” The study was published March 13, 2012 in the journal AIDS.

Related Links:

Research Triangle Institute



CELLAVISION AB
EUROIMMUN AG
KARL HECHT GMBH & CO KG
WATERS CORPORATION

Channels

Clinical Chemistry

view channel
Image: The Avance III 600 spectrometer for proton nuclear magnetic resonance analysis (Photo courtesy of Bruker).

New Blood Test Can Predict Future Breast Cancer

The analysis of a blood sample could predict if a woman will get breast cancer within two to five years which could create a paradigm shift in early diagnosis of this malignant neoplasm as well as other diseases.... Read more

Genetic Tests

view channel

Buccal Swabs Replace Phlebotomy for Postnatal and Pediatric DNA Collection

Collection of samples for prenatal and pediatric DNA sequencing procedures is now available via buccal swabs rather than by phlebotomy. CombiMatrix Corporation (Irvine, CA, USA) a molecular diagnostics company specializing in DNA-based diagnostic services for prenatal, postnatal, and pre-implantation genetic testing... Read more

Hematology

view channel
Image: The new point-of-care Hemo Control delivers laboratory-accurate hemoglobin and hematocrit results in one simple test and uniquely offers flexible and enhanced data management with bi-directional interface (Photo courtesy of EKF Diagnostics).

Next-Generation Hemoglobin Analyzer Uniquely Ensures Bi-Directional Data Management Future Proofing

A new point-of-care (POC) diagnostics analyzer delivers quantitative laboratory-accurate hemoglobin and hematocrit results in one simple test and uniquely enables upgrade with data management functionality... Read more

Industry News

view channel

Main Factors Driving Revenue Growth in Clinical Chemistry Identified

According to a report by Kalorama Information (New York, NY, USA), overall growth in the clinical chemistry market will be modest, driven mainly by new tests and demographic changes, including an aging population and increasing number of people at risk of cardiovascular disease, such as those with hypertension, diabetes... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.