Features | Partner Sites | Information | LinkXpress
Sign In
PURITAN MEDICAL
RANDOX LABORATORIES
FOCUS DIAGNOSTICS, INC.

Antibodies to Carbamylated Proteins Provide Insight into Rheumatoid Arthritis

By Labmedica International staff writers
Posted on 05 Feb 2013
Detection of antibodies to carbamylated proteins (anti-CarP) is an important advance in the diagnosis of Rheumatoid Arthritis (RA).

A study published in 2012 by a team at Leiden University Medical Center (LUMC; Leiden, The Netherlands) in Proceedings of the National Academy of Sciences of the United States of America (PNAS) showed that Immunoglobulin G (IgG) and IgA antibodies recognizing carbamylated antigens were present in about 50% of RA patients. Anti-CarP antibodies recognize homocitrulline and are therefore distinct from anticitrullinated protein antibodies (ACPA), including anti-cyclic citrullinated peptide (anti-CCP), a biomarker commonly used to diagnose RA. Anti-CarP IgG and IgA were detected in 16% and 30% of ACPA negative RA patients respectively. Additionally, anti-CarP antibodies were shown to be predictive of a more severe course of disease as measured by radiological progression in ACPA negative RA patients.

LUMC and Inova (San Diego, CA, USA) have announced the completion of an exclusive, worldwide license agreement for technology developed at LUMC to detect antibodies to carbamylated proteins (anti-CarP). "The detection of autoantibodies in sera of RA patients has provided important insight into the processes that initiate and drive RA. Since anti-CarP antibodies can also be detected in a subgroup of patients for whom so far no serological markers were available we believe this may provide new insight into the pathogenesis of RA,"said Dr. Leendert Trouw, assistant professor at LUMC.

Prof. Tom Huizinga, head of the department of Rheumatology at LUMC added "With new treatment options at hand it is now possible to apply early and aggressive treatment. Understanding which patients would benefit most from such an intervention is important to maximize efficiency, and detection of anti-CarP antibodies may identify such patients."

The LUMC is part of the Dutch Federation of University Medical Centers (NFU). The NFU is a collaboration of the eight University Medical Centers of The Netherlands.

Related Links:

Leiden University Medical Center
Inova



Dubai Bio Expo-2015
DIASYS DIAGNOSTIC SYSTEMS
KARL HECHT GMBH & CO KG

Channels

Genetic Tests

view channel
Image: The final result of a DNA sequencing process, with each color representing one of the four base chemicals, adenine, guanine, cytosine and thymine, that comprise DNA (Photo courtesy of Gerald Barber).

Gene Sequencing Reference Standard Increases Accuracy for Medical Laboratories

To reduce the variability in genetic test results that has been observed across different clinical laboratories and pathology groups, a new standard DNA reference has been introduced, which will improve... Read more

Hematology

view channel
Image: Immunochemistry of bone marrow biopsy from an acute myeloid leukemia patient showing sheets of CD34 positive cells; corresponding bone marrow aspirate showed only 20% blasts (Photo courtesy of All India Institute of Medical Sciences).

Immunohistochemistry Assesses Early Response in Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a heterogeneous disease with respect to prognosis and early response assessment has an established role as predictor of remission rate, and overall and disease-free survival.... Read more

Industry News

view channel

Partners to Develop and Commercialize Noninvasive Tests for Bladder Cancer

An agreement between a major European university medical center and a multinational biotechnology company was designed to promote commercialization and further development of a liquid biopsy test for the diagnosis of bladder cancer. The liquid biopsy test is based on bladder cancer DNA methylation biomarkers developed... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.