Features | Partner Sites | Information | LinkXpress
Sign In
RANDOX LABORATORIES
FOCUS DIAGNOSTICS, INC.
Biostrata Ltd on behalf of Thermo

Spinal Fluid Marker Strongly Predicts Mental Decline

By Labmedica International staff writers
Posted on 19 Mar 2012
A novel marker of Alzheimer's disease (AD) can predict how rapidly a patient's memory and other mental abilities will decline after the disorder is diagnosed.

Higher levels of the marker, visinin-like protein 1 (VILIP-1), in the cerebrospinal fluid (CSF) of Alzheimer's patients have been linked to a more rapid mental decline in the years that followed.

Scientists at Washington University School of Medicine (St. Louis, MO, USA) studied 60 individuals with a clinical diagnosis of very mild or mild AD and measuring baseline CSF protein levels of VILIP-1, Tau, phosphorylated Tau-181 (p-tau181), and amyloid-beta 1–42 (Aβ42), and these were followed longitudinally for an average of 2.6 years.

Baseline CSF VILIP-1 and VILIP-1/Aβ42 levels predicted rates of future decline in the clinical dementia rating and global composite scores over the follow-up period. Individuals with CSF VILIP-1 equal to or greater than 560 pg/mL progressed much more rapidly than individuals with lower values. CSF tau, p-tau181, tau/ Aβ42, and p-tau181/ Aβ42 also predicted more rapid cognitive decline overtime. Scientists think VILIP-1 serves as a calcium sensor in brain cells. It is released into the cerebrospinal fluid when the cells are injured. CSF samples were analyzed for total tau, p-tau181, Aβ42 using Innotest, (Innogenetics, Ghent, Belgium), and CSF Aβ40 by an enzyme-linked immunosorbent assay. CSF samples were analyzed for VILIP-1 by Erenna, a microparticle-based immunoassay (Singulex, CA, USA).

Rawan Tarawneh, MD, the lead author of the study, said "VILIP-1 appears to be a strong indicator of ongoing injury to brain cells as a result of Alzheimer's disease. That could be very useful in predicting the course of the disease and in evaluating new treatments in clinical trials. These results are intriguing, but we need a larger study to fully understand how the insights provided by VILIP-1 compare to those we can gain from other markers.” The study was published online on February 22, 2012, in the journal Neurology.

Related Links:
Washington University School of Medicine
Innogenetics
Singulex



KARL HECHT GMBH & CO KG
DIASYS DIAGNOSTIC SYSTEMS
EUROIMMUN AG
WATERS CORPORATION

Channels

Genetic Tests

view channel
Image: Histopathology of a spinal cord from an infant with multiple joint contractures present at birth (Photo courtesy of Dimitri P. Agamanolis, MD).

Infant Stiff-Joint Syndromes Matched to Possible Genetic Origins

There are over 400 specific disorders that are, or can be, associated with multiple contractures in the newborn and a better understanding of disorders with contractures and their associated genetics is... Read more

Pathology

view channel

Panel of Bloodstream MicroRNAs Predicts Damage from Radiation Exposure

A panel of microRNAs (miRNAs) that can be measured in blood samples is able to predict the extent of long-term radiation injury and likelihood of survival following exposure to high doses of radiation. Accidental radiation exposure is a threat to human health that necessitates effective clinical planning and diagnosis.... Read more

Industry News

view channel

Main Factors Driving Revenue Growth in Clinical Chemistry Identified

According to a report by Kalorama Information (New York, NY, USA), overall growth in the clinical chemistry market will be modest, driven mainly by new tests and demographic changes, including an aging population and increasing number of people at risk of cardiovascular disease, such as those with hypertension, diabetes... Read more
 

Events

27 May 2015 - 29 May 2015
02 Jun 2015 - 03 Jun 2015
06 Jun 2015 - 09 Jun 2015
Copyright © 2000-2015 Globetech Media. All rights reserved.