Features | Partner Sites | Information | LinkXpress
Sign In
RANDOX LABORATORIES
FOCUS DIAGNOSTICS, INC.
GLOBETECH PUBLISHING

Serum Adipokines Associated With Diabetic Risk Factors

By Labmedica International staff writers
Posted on 10 Jan 2012
Cytokines produced by the adipose tissue are known as adipokines and abnormal levels in the serum maybe cardiovascular risk factors for diabetic patients.

The relationship of the serum profile of adipokines, such as leptin, adiponectin, resistin, and interleukin 6 (IL-6) has been evaluated with these risk factors for obese patients with diabetes mellitus type 2 (DM2).

In a prospective study at the University of Valladolid (Spain), 108 obese patients with DM2 were enrolled and their blood was analyzed. A complete biochemical, anthropometric, and nutritional evaluation was performed. Basal glucose, C-reactive protein (CRP), insulin, total cholesterol, low-density lipoprotein (LDL)-cholesterol, high-density liporotein (HDL)-cholesterol, triglycerides blood, and adipokines (leptin, adiponectin, resistin, and IL-6) levels were measured in fasting condition.

Interleukin 6 was measured by an enzyme-linked immunosorbent assay ELISA (R&D systems, Inc.; Minneapolis, MN, USA) with a sensitivity of 0.5 pg/mL. Normal values of IL6 were 1.12-12.5 pg/mL. Adiponectin was measured by an ELISA, also from R&D systems, with a sensitivity of 0.246 ng/mL and a normal range of 865-21,424 ng/mL. Resistin was measured by an ELISA (Biovendor Laboratory, Inc.; Brno, Czech Republic) with a sensitivity of 0.2 ng/mL and a normal range of 4-12 ng/mL. Leptin was measured by ELISA (Diagnostic Systems Laboratories, Inc.; Webster, TX, USA) with a sensitivity of 0.05ng/mL and a normal range of 10-100 ng/mL.

The authors concluded that the serum profile of adipokines is related with different cardiovascular risk factors and anthropometrical variables in obese patients with diabetes type 2. The serum profile of the adipokines showed that only leptin levels were higher in women than in men. These associations have different implications with each adipokine and each parameter was shown by multivariate analysis. The study was published in the November 2011 issue of Journal of Clinical Laboratory Analysis .

Related Links:
University of Valladolid
R&D systems
Biovendor Laboratory


EUROIMMUN AG
PURITAN MEDICAL
Sekisui Diagnostics
comments powered by Disqus
Life Technologies

Channels

Pathology

view channel
Image: Glioblastoma multiforme (GBM) (Photo courtesy of the University of California, San Diego School of Medicine).

Brain Tumor Chemotherapy Biomarkers Identified

Cancer researchers have identified a new biomarker that they believe can predict whether glioblastoma multiformes (GBMs), the most common and aggressive type of malignant brain tumor, will be susceptible... Read more

Lab Technology

view channel
Image:  The Becton Dickinson fluorescent activated cell sorter FACScan (Photo courtesy of the Albert Einstein College of Medicine).

Noninvasive Method Captures Circulating Tumor Cells

A clinically proven, noninvasive fluorescence virus-guided capture system of human colorectal circulating tumor cells (CTCs) from blood samples for genetic testing has been introduced. This noninvasive... Read more

Industry News

view channel

Beckman Coulter Acquires Siemens Healthcare Diagnostics’ Clinical Microbiology Business

Beckman Coulter (Brea, CA, USA), an indirect wholly-owned subsidiary of Danaher Corp. (Washington DC, MD, USA) has entered into a definitive agreement to purchase the clinical microbiology business of Siemens Healthcare Diagnostics (Chicago, IL, USA). The transaction is expected to close in the first quarter of 2015.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.