Features | Partner Sites | Information | LinkXpress
Sign In
RANDOX LABORATORIES
AB Sciex
FOCUS DIAGNOSTICS, INC.

Test Aids Diagnosis of Preeclampsia

By Labmedica International staff writers
Posted on 09 Jan 2012
Image: The Alere Triage MeterPro (Photo courtesy of Alere).
Image: The Alere Triage MeterPro (Photo courtesy of Alere).
A test with high sensitivity and specificity level helps diagnosis of early onset preeclampsia.

The triage placental growth factor (PLGF) test is a fluorescence immunoassay, which, when used in conjunction with a Triage Meter enables the quantitative determination of PLGF in ethylenediaminetetraacetic acid (EDTA) anticoagulated plasma samples. Together with other diagnostic and clinical information, the test aids in the diagnosis of preeclampsia.

The Alere (Linz, Austria) Triage PLGF test can provide a PLGF level from a maternal plasma specimen in just 15 minutes. The Triage MeterPro is a portable fluorescence instrument used to measure the results of the Triage tests from Alere. The Triage MeterPro can be used in a laboratory or in a point-of-care setting. It uses a Class 1 laser as a light source. Light from the laser hits a test device that has been inserted in the meter. This causes the fluorescent dye in the test device to give off energy. The more energy the fluorescent dye gives off, the stronger the signal.

The current criteria for defining preeclampsia (raised blood pressure and protein in urine) are nonspecific, appear late in the development of the disease, and result in over-diagnosis because of their poor specificity.

The Lancet online December 15, 2011 published an editorial that highlights the fact that many maternal deaths in the UK are associated with substandard care and are potentially preventable. The article suggests that it is the failure to diagnose or appropriately manage preeclampsia, which is the most common cause of maternal death.

Preeclampsia is a serious and potentially fatal condition that arises in pregnancy, usually in the second or third trimester. The exact cause is unknown but it is thought to be related to a problem with the placenta. The nonspecificity of signs and symptoms contribute to making clinical diagnosis a significant challenge, this represents a high risk to both mother and child.

Prof. Christopher Redman, emeritus professor of Obstetrics at John Radcliffe Hospital (Oxford, United Kingdom) commented, “A reliable and specific test that aids in the diagnosis of those aspects of the preeclampsia syndrome that jeopardize the safety of mother and/or unborn baby would be invaluable. Alere Triage PLGF is a major advance in the assessment for preterm disease.”

Related Links:
Alere
John Radcliffe Hospital



PURITAN MEDICAL
77 ELEKTRONIKA
DiagCor Bioscience
comments powered by Disqus
Sekisui Diagnostics

Channels

Clinical Chemistry

view channel
Image: The Cobas 6000 Multipurpose Clinical Laboratory analyzer (Photo courtesy of Roche Diagnostics).

Low Density Lipoprotein Apolipoprotein-B Assay Validated

The relationship between apolipoprotein-B (Apo-B) concentration and the risk of developing cardiovascular disease (CVD) is more robust than the relationship between low density lipoprotein cholesterol... Read more

Genetic Tests

view channel
Histopathology of colonic adenocarcinoma; the glands are enlarged and filled with necrotic debris (Photo courtesy of the University of Utah).

Promising Blood Biomarkers Isolated for Colorectal Cancer

The search for blood-borne biomarkers that could be used to screen for colorectal cancer (CRC) has uncovered two promising candidates that may one day lead to the development of a simple blood test.... Read more

Microbiology

view channel
Image: IC 3D technology rapidly detects bacterial infection in blood samples (Photo courtesy of University of California, Irvine).

DNA-Based Droplet System Rapidly Detects Bacterial Infection in the Bloodstream

A new test for bacterial infection in the bloodstream is based on an innovative DNA labeling and particle counting system. Investigators at the University of California, Irvine (USA) recently described... Read more

Industry News

view channel

Collaboration to Bring Personalized Cancer Care to Singapore

A German company specializing in cancer diagnosis will be extending its expertise in personalized care to the health care market in Singapore. New Oncology (Cologne, Germany) announced recently that it has entered into a collaboration agreement with the National Cancer Centre Singapore (Singapore). New Oncology will... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.