Features | Partner Sites | Information | LinkXpress
Sign In
RANDOX LABORATORIES
AB Sciex
FOCUS DIAGNOSTICS, INC.

New Prostate Cancer Test Better Than PSA Test

By Labmedica International staff writers
Posted on 30 May 2011
A new test for prostate cancer that measures levels of prostate specific antigen (PSA) as well as six specific antibodies found in the blood of men with the disease is more sensitive and more specific than the conventional PSA test used today, according to a new study.

Researchers at the University of California Los Angeles (UCLA; USA) developed the new test, called the A+PSA assay, which checks simultaneously for PSA and antibodies to six prostate-cancer associated antigens in a single reaction test done in a laboratory. The six specific prostate-cancer associated antigens include NY-ESO-1, SSX-2,4, XAGE-lb, AMACR, p90 and LEDGF, which are found predominantly in patients with prostate cancer and not in benign prostate conditions. The new test takes about two hours, similar to the PSA test.

The test results in an index used to diagnose prostate cancer, with a score of 0-0.5 indicating a benign result and 0.5-1 indicating the presence of cancer. In the new test, sensitivity--the percentage of men with prostate cancer who were correctly identified as having a malignancy--was 79%, compared to the 52% found in PSA testing. Specificity--the percentage of healthy men who were correctly identified as not having prostate cancer--was 84%, compared to the 79% found when testing for PSA alone. Additionally, while the rate of false-positives using conventional PSA testing is 21%, the new A+PSA assay delivers a false-positive rate of 16%. The study was published in the May 2011 issue of Translational Medicine.

"Science has improved so much since the PSA test was developed and I think it's time for a more specific and sensitive test to be developed," said senior author Gang Zeng, MD, PhD, an associate professor of urology. "I think we have a test that has great potential to improve the diagnosis of prostate cancer. I knew it would be better than the classic PSA test, but I was amazed at how much better it really was in this study."

"While measuring PSA is useful in identifying men with prostate cancer, some men with prostate cancer have a normal PSA level and small elevations in PSA above normal may be produced both by prostate cancer as well as an enlarged but benign prostate," added coauthor associate professor of urology Allan Pantuck, MD, MS. "Combining PSA with a panel of tests that measure an individual man's anticancer immune response may better identify who has prostate cancer and who can be spared an unnecessary invasive biopsy."

The conventional PSA test for prostate cancer has been used for nearly 30 years and is not specific enough in delineating between malignancies and nonmalignant diseases of the prostate, such as benign prostatic hyperplasia (BPH), an enlarging of the prostate common in aging men that increases PSA levels.

Related Links:

University of California Los Angeles




DiagCor Bioscience
PURITAN MEDICAL
77 ELEKTRONIKA
comments powered by Disqus
Sekisui Diagnostics

Channels

Clinical Chemistry

view channel
Image:  The Agilent 6890 GC with 5973 Mass Spectrometer and Tekmar Velocity XPT Purge & Trap (Photo courtesy of Gen Tech).

Low Levels of Prohormone Predicts Coronary Heart Disease

The adrenal sex hormone dehydroepiandrosterone (DHEA), which is present in serum mainly as the sulfate DHEA-S, is the most abundant steroid hormone in human blood and its levels decline dramatically with age.... Read more

Genetic Tests

view channel
Image: The BioMark HD and EP1 platform with Digital Array Integrated Fluidic Circuits for quantitative real-time polymerase chain reaction (Photo courtesy of Fluidigm).

Molecular Test Identifies Acute Transplant Rejection

The development of noninvasive molecular assays to improve disease diagnosis and patient monitoring is a critical need in renal transplantation, as acute rejection (AR) increases the risk for chronic graft... Read more

Microbiology

view channel
Image: The causative parasite of Chagas disease Trypanosoma cruzi in a blood film (Photo courtesy of the CDC - US Centers for Disease Control and Prevention).

Undiagnosed Chagas Disease Emerging as Public Health Threat

Chagas disease or American trypanosomiasis is typically spread to people through the feces of blood-sucking triatomine bugs sometimes called kissing bugs because they feed on people's faces during the night.... Read more

Pathology

view channel

Identification of Independent Primary Lung Tumors and Tumors with Metastases Using Next-Generation DNA Sequencing

A team of oncologists and surgeons used a next-generation DNA sequencing (NGS) technique to determine whether non-small-cell lung cancer patients with multiple tumors carried independent primary tumors or a single primary tumor that had metastasized. For patients with multiple tumors, distinguishing independent primary... Read more

Industry News

view channel

Oncology Companion Diagnostics Sector Grows to Over USD 1 Billion

The market for diagnostic test and pharmaceutical drug pairs for cancer treatment has grown significantly, according to the report “Companion Diagnostic Markets” from healthcare market research firm Kalorama Information (New York City, NY, USA). The global companion diagnostics (CDx) market is valued at about USD 1.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.