We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
PURITAN MEDICAL

SYSMEX-EUROPA

Sysmex Europe designs and produces laboratory and hematology diagnostic solutions, including instruments, reagents, c... read more Featured Products: More products

Download Mobile App




Events

09 Apr 2024 - 12 Apr 2024
15 Apr 2024 - 17 Apr 2024
23 Apr 2024 - 26 Apr 2024

Diagnostic Predictive Value of Platelet Indices Evaluated

By LabMedica International staff writers
Posted on 31 Aug 2016
Print article
Image: The XT 2000i fully automated hematology analyzer (Photo courtesy of Sysmex).
Image: The XT 2000i fully automated hematology analyzer (Photo courtesy of Sysmex).
The two main causes of thrombocytopenia excluding pseudo thrombocytopenia are increase destruction or peripheral consumption also known as hyper-destructive thrombocytopenia. Decreased platelet productions or hypo-production thrombocytopenia are associated with a number of bone marrow diseases.

The gold standard method for discriminating the causes of immune thrombocytopenic purpura (ITP), disseminated intravascular coagulation (DIC), and thrombotic thrombocytopenic purpura (TTP) is bone marrow examination. Due to its invasiveness and being unfriendly for the patients, this procedure is not recommended as first line diagnosis. ITP still remains a diagnosis by exclusion due to lack of accurate clinical and laboratory parameters.

Hematologists at the College of Health Sciences (Addis Ababa University, Ethiopia) conducted a prospective cross-sectional study on 83 thrombocytopenic patients whose platelet count was less than 150 × 109/L. From these, 50 patients had hypoproductive and the rest 33 had Immune Thrombocytopenia Purpura (ITP). Age and sex matched 42 healthy controls were included as a comparative group. Bone marrow examination was performed in all 50 hypoproductive patients and in 10 of the 33 ITP patients as part of their medical follow up and diagnosis. Females were the predominant study participants in ITP patients, while males were predominant in the hypo productive group.

Blood sample for complete blood count (CBC) analysis was collected into 5 mL EDTA anti-coagulated tube and CBC analysis was performed using the XT 2000i fully automated hematology analyzer (Sysmex Corporation, Kobe, Japan). This analyzer measures white blood cells (WBC) and reticulocytes with an optical detector block based on the flow cytometry principle, red blood cells (RBC) and platelet counts are analyzed via the impedance method. The performance of the instrument was monitored by running quality control materials. A peripheral blood smear was also reviewed to estimate platelet counts, rule out pseudo thrombocytopenia and fragments of cells like shistocytes.

All platelet indices were significantly higher in ITP patients than in hypoproductive thrombocytopenic patients. In particular mean platelet volume (MPV) and Platelet Large Cell-Ratio (P-LCR) have larger area under ROC curve, 0.876 and 0.816, respectively, indicating a better predictive capacity, sensitivity and specificity in discriminating the two causes of thrombocytopenia. The indices were still significantly higher in ITP patients compared to 42 healthy controls. A significant negative correlation was observed between platelet count and platelet indices in ITP patients.

The authors concluded that Platelet Distribution Width (PDW), MPV, and P-LCR help in predicting thrombocytopenic patients as having ITP or hypoproductive thrombocytopenia. If these indices are used in line with other laboratory and clinical information, they may help in delaying/ avoiding unnecessary bone marrow aspiration in ITP patients or supplement a request for bone morrow aspiration or biopsy in hypoproductive thrombocytopenic patients. The study was published on July 1, 2016, in the journal BMC Hematology.

Related Links:
Addis Ababa University
Sysmex
Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Specimen Collection & Transport
Complement 3 (C3) Test
GPP-100 C3 Kit
New
Gold Member
TORCH Panel Rapid Test
Rapid TORCH Panel Test

Print article

Channels

Clinical Chemistry

view channel
Image: Reaching speeds up to 6,000 RPM, this centrifuge forms the basis for a new type of inexpensive, POC biomedical test (Photo courtesy of Duke University)

POC Biomedical Test Spins Water Droplet Using Sound Waves for Cancer Detection

Exosomes, tiny cellular bioparticles carrying a specific set of proteins, lipids, and genetic materials, play a crucial role in cell communication and hold promise for non-invasive diagnostics.... Read more

Molecular Diagnostics

view channel
Image: The cobas Malaria test is the first FDA-approved molecular test to screen U.S. blood donors for malaria (Photo courtesy of Roche)

First FDA-Approved Molecular Test to Screen Blood Donors for Malaria Could Improve Patient Safety

Malaria, a serious illness that often leads to death, is spread by a specific mosquito species that infect humans with a parasite. Other transmission modes include blood transfusions, organ transplants,... Read more

Pathology

view channel
Image: The medical office procedure detects the key biomarker in Parkinson’s and related neurodegenerative diseases (Photo courtesy of BIDMC)

Simple Skin Biopsy Test Detects Parkinson’s and Related Neurodegenerative Diseases

Parkinson's disease and a group of related neurodegenerative disorders known as synucleinopathies impact millions globally. These conditions, including Parkinson’s disease (PD), dementia with Lewy bodies... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.