Features | Partner Sites | Information | LinkXpress
Sign In
Bio-Rad Diabetes Division
FOCUS DIAGNOSTICS, INC.
RANDOX LABORATORIES

Genetic Test Reveals Predisposition for Abnormal Blood Clotting

By Labmedica International staff writers
Posted on 21 Feb 2013
The non-O ABO blood type is the most important risk factor for venous thromboembolism, making up 20% of inferred risk for the condition.

Individuals with an A or B blood type have an increased risk of venous thromboembolism or blood clots in their veins and myocardial infarction compared with individuals with O blood type.

A retrospective study was carried out by scientists at the Copenhagen University Hospital (Denmark) who looked at data on 66,001 people who had been followed for 33 years from 1977 through 2010 to determine whether ABO blood type is associated with an increased risk of venous blood clots in the general population. They determined ABO genotype from single nucleotide polymorphisms (SNP) in the ABO gene. The genotypes were validated by sequencing.

The scientists also measured the following using standard hospital assays: plasma levels of total cholesterol, low-density lipoprotein cholesterol, high density lipoprotein cholesterol, platelets, mean platelet volume, leukocytes, coagulation factors (II, VII, X), international normalized ratio, activated partial thromboplastin time, high-sensitivity C-reactive protein and complement C3.

The team found that the risk increased when ABO blood type was combined with factor V Leiden R506Q genotype or prothrombin G20210A genotype. These genetic mutations were associated with an increased risk of venous thromboembolisms. This finding confirms the conclusion of other studies. The scientists also found an 11-fold increased risk of venous thromboembolism for people with the prothrombin G20210A mutation. The population attributable risk of venous thromboembolism was 20% for ABO blood type, 10% for factor V Leiden R506Q and 1% for prothrombin G20210A.

Børge G. Nordestgaard, MD, DMSc, a coauthor of the study said, "We found an additive effect of ABO blood type on risk of venous thromboembolism when combined with factor V Leiden R506Q and prothrombin G20210A; ABO blood type was the most important risk factor for venous thromboembolism in the general population." The authors concluded that ABO blood type should be considered for inclusion in genetic screening for thrombophilia. The study was published February 4, 2013, in the Canadian Medical Association Journal.

Related Links:
Copenhagen University Hospital


PURITAN MEDICAL
DiagCor Bioscience
77 ELEKTRONIKA
comments powered by Disqus
Sekisui Diagnostics

Channels

Clinical Chemistry

view channel
Image: The Cobas 6000 Multipurpose Clinical Laboratory analyzer (Photo courtesy of Roche Diagnostics).

Low Density Lipoprotein Apolipoprotein-B Assay Validated

The relationship between apolipoprotein-B (Apo-B) concentration and the risk of developing cardiovascular disease (CVD) is more robust than the relationship between low density lipoprotein cholesterol... Read more

Genetic Tests

view channel
Histopathology of colonic adenocarcinoma; the glands are enlarged and filled with necrotic debris (Photo courtesy of the University of Utah).

Promising Blood Biomarkers Isolated for Colorectal Cancer

The search for blood-borne biomarkers that could be used to screen for colorectal cancer (CRC) has uncovered two promising candidates that may one day lead to the development of a simple blood test.... Read more

Microbiology

view channel

Novel Sequence Analysis Services Improve Pathogen Identification

A set of new-generation sequencing (NGS) services provides unique tools for more effective identification of known and unknown microorganisms, including bacterial, viral, fungal, and protozoan parasite pathogens. Aperiomics (Ashburn, VA, USA) has now introduced its breakthrough Absolute-NGS Pathogen Detection Platform... Read more

Industry News

view channel

Market for qPCR Exceeds USD 3 Billion

The market for real-time quantitative polymerase chain reaction (qPCR) was valued at about USD 3.2 billion for 2013 according to Kalorama Information (New York, NY, USA) an increase from USD 2.8 billion in 2011. The healthcare market researcher said that the testing system is considered the workhorse of research providing... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.