Features | Partner Sites | Information | LinkXpress
Sign In
FOCUS DIAGNOSTICS, INC.
RANDOX LABORATORIES
GLOBETECH PUBLISHING

Leukocyte Ratio Predicts Ulcerative Colitis Severity

By Labmedica International staff writers
Posted on 11 Feb 2013
Blood neutrophil-to-lymphocyte (N/L) ratio is an indicator of the overall inflammatory status of the body, and an alteration in N/L ratio may be found in ulcerative colitis (UC) patients.

An optimal test has not yet been developed for UC and therefore the adjunctive use of additional blood markers may add a significant advantage for predicting disease severity and achieving diagnostic precision.

Medical scientists at Erciyes University (Kayseri, Turkey) enrolled 26 UC patients, 18 males and 8 females, and 28 healthy controls, 10 males and 18 females in the study. Complete blood counts, erythrocyte sedimentation rates (ESR), and C-reactive protein levels (CRP) were established for both patients and controls. The white blood count (WBC), neutrophil, and lymphocyte counts were recorded, and the N/L ratios were calculated from these parameters. The median disease duration in UC patients was 2.75 years.

The N/L ratios of patients with active UC were significantly higher at 3.85 ± 2.71 than those of inactive UC at 2.40 ± 1.05 and controls at 1.77 ± 0.68 were. The optimum N/L ratio cut-off point for active UC was 2.47. There was no significant difference between inflammation parameters, disease extension, and disease activity. The other inflammation markers such as ESR and CRP were also higher in the patients with active UC.

The authors concluded that in patients with UC, the N/L ratio is strongly associated with active disease. Unlike many other noninvasive markers of UC, the N/L ratio is inexpensive and readily available. Although the accuracy of the N/L ratio for detecting active UC is suboptimal, the ratio is an easily derived measure that might, in combination with other markers, assist in identifying patients at increased risk of active and severe disease. The study was published in the January 2013 issue of the Journal of Clinical Laboratory Analysis.

Related Links:

Erciyes University



VIRCELL
DiagCor Bioscience
Sekisui Diagnostics
comments powered by Disqus
Life Technologies

Channels

Clinical Chemistry

view channel
Image: The URiSCAN Super Plus reflectance meter (Photo courtesy of YD Diagnostics).

Semiquantitative Urine Dipstick Evaluated for Microalbuminuria Screening

The urine microalbumin test is used as a screening test for the diagnosis of renal complications in diseases, such as diabetic nephropathy, cardiovascular disease, and hypertension. A urine dipstick... Read more

Microbiology

view channel
Image: The adult free-living female Strongyloides stercoralis with a row of eggs within the body of the nematode (Photo courtesy of the CDC - Centers for Disease Control and Prevention).

Rapid Serological Assay Developed for Strongyloidiasis

Several imperfect methods exist for diagnosing strongyloidiasis and stool examination with microscopic identification of larvae considered the gold standard diagnostic procedure, showing good specificity... Read more

Pathology

view channel
Image: The BD Viper LT System for fully automated, integrated molecular testing on a table top analyzer (Photo courtesy of BD Diagnostics).

Modern Methods Accurately Detects Cervical Cancer

The newer Papanicolaou test (Pap tests) and human papilloma virus (HPV) screening more accurately identify precancerous cellular changes that potentially develop into cervical cancer. Compared to a... Read more

Lab Tech.

view channel
Image: RNAscope detects TP63 mRNA expression in human prostate tissue (Photo courtesy of Advanced Cell Diagnostics).

RNA Biomarker Assay Now Manufactured According to Strict ISO Regulatory Criteria

A line of diagnostic kits that measures RNA biomarkers with single-molecule sensitivity is now being manufactured under the stringent requirements of ISO 13485:2003 certification. Advanced Cell Diagnostics, Inc.... Read more

Industry News

view channel

Social Diagnostics Start-Up to Provide Simple, Affordable Tests Worldwide

The Royal Tropical Institute (KIT; Amsterdam, Netherlands) is establishing a nonprofit, social diagnostics company that develops and markets tests for the diagnosis of poverty-related diseases. Infectious diseases have a global impact; they take no account of national borders and influence the stability of societies... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.