Features | Partner Sites | Information | LinkXpress
Sign In
FOCUS DIAGNOSTICS, INC.
RANDOX LABORATORIES
GLOBETECH PUBLISHING LLC

Assay Targets Early Lung Cancers for Adjuvant Therapy

By Labmedica International staff writers
Posted on 07 Mar 2013
A novel genetic assay helps identify patients with early, aggressive lung cancer who might benefit from adjuvant therapy.

The assay provides considerably more prognostic information than do conventional criteria as defining high-risk tumors warranting treatment that was proposed by the National Comprehensive Cancer Network (NCCN; Fort Washington, PA, USA).

The assay results were used to stratify the 269 study patients who had undergone resection of T1a node-negative and nonmetastatic, nonsquamous, non-small-cell lung cancer (NSCLC) into groups with distinctly different five-year survival rates. The novel assay assesses expression of 14 genes involved in lung cancer tumorigenesis, including ones on the epidermal growth factor receptor (EGFR)and the Kirsten ras oncogene homolog (KRAS) signaling pathways.

The assay is the only lung cancer signature to undergo blinded validation in two large cohorts from different countries, one in the United States of America and one in China. It is marketed as Pervenio Lung RS by Life Technologies (Carlsbad, CA, USA). The main study results, reported showed that the 5-year actuarial overall survival was 83%, 69%, and 52% among patients defined by the assay as low-, medium-, and high-risk groups, respectively. In multivariate analyses, relative to their counterparts in the low-risk group, patients in the intermediate-risk group had a 2.0-fold higher risk of death and patients in the high-risk group had a 3.3-fold higher risk.

The assay, which is a quantitative polymerase chain reaction (qPCR)-based, also showed good risk discrimination in analyses restricted to the smallest of tumors, those measuring 1.5 cm or less and even those measuring 1.0 cm or less. When compared with tumor size alone, the combination of the assay and tumor size significantly improved on the identification of patients who died.

Johannes R. Kratz, MD, the lead author of the study and a postdoctoral fellow at the University of California, San Francisco (CA, USA) said, “Despite the popularity and endorsement of our radiology colleagues for techniques such as stereotactic radiation for small T1aN0M0 tumors (i.e., Stage IA, no adverse features, Breslow ≤ 1 mm, T1a, no ulceration (U-), mitotic rate less than 1 mm2) , we should remember that these techniques don’t provide us with potentially important lung tissue that can provide prognostic and predictive information.” The study data was reported at Annual Meeting of the Society of Thoracic Surgeons, January 26–30, 2013, in Los Angeles (CA. USA).

Related Links:

National Comprehensive Cancer Network
Life Technologies
University of California, San Francisco



CELLAVISION AB
KARL HECHT GMBH & CO KG
MEDLAB Asia

Channels

Microbiology

view channel
Image: The Xpert MTB/RIF cartridge-based, fully automated molecular diagnostic test for tuberculosis (Photo courtesy of Cepheid).

Test Helps Physicians Remove Suspected TB Patients from Isolation

Tuberculosis (TB) is caused by the Mycobacterium tuberculosis complex (MTB-complex) and usually attacks the lungs and many people carry the MTB-complex bacteria without ever developing active disease.... Read more

Lab Tech.

view channel
Image:  The Flame – a miniature spectrometer for medical diagnostics, biotechnology, and life sciences, that brings flexible optical sensing power to laboratory and point-of-care instrument integration (Photo courtesy of Ocean Optics).

Next Generation Miniature Spectrometer Brings Flexibility to Diagnostics and Biotechnology

The mini spectrometer combines decades of pioneering miniature spectrometer design expertise with leading techniques, adding flexible optical sensing power to laboratory and point-of-care instrument integration.... Read more

Industry News

view channel
Image: Under a new partnership for liquid handling measurement automation, Artel will provide STRATEC’s innovative “Tholos” technology, which measures liquid and solid contents of 96- and 384-well microplates, under the name Artel “SDS” - Sample Detection System (Photo courtesy of Artel).

Artel Expands Portfolio with STRATEC Partnership for Automation Technology

Artel (Westbrook, Maine, USA), a leader in laboratory liquid handling measurement systems, and STRATEC Biomedical AG (Birkenfeld, Germany), a leader in automated systems for clinical diagnostics and biotechnology,... Read more
 

Events

05 Mar 2015 - 08 Mar 2015
08 Mar 2015 - 12 Mar 2015
18 Mar 2015 - 20 Mar 2015
Copyright © 2000-2015 Globetech Media. All rights reserved.