Features | Partner Sites | Information | LinkXpress
Sign In
FOCUS DIAGNOSTICS, INC.
RANDOX LABORATORIES
GLOBETECH PUBLISHING

“Multi-Omic” Diagnostic Test Will Accelerate Implementation of Personalized Healthcare

By Labmedica International staff writers
Posted on 06 Mar 2013
Personalized healthcare, giving the appropriate therapy to the individual patient, depends on high-value diagnostics that can guide “which patients” will respond to “which therapy” within a specific disease.

Sylventa (Cambridge, MA, USA) is developing Systems Diagnostics (SysDx) a novel diagnostic test that can consist of “multi-omic” biomarkers selected through a rigorous Big Data analysis of a patient’s biological profile including genomic, epigenomic, transcriptomic, proteomic, metabolomic, and electronic medical record information.

From this analysis, Selventa will generate a differentiated and clinically relevant report that physicians and patients can use to improve therapy selection.

Most chronic diseases, including asthma, diabetes, Parkinson’s disease, late-onset Alzheimer’s disease, and most cancers, are too complex to rely on genomic variations alone. Instead, the molecular drivers of disease are manifested across thousands of interrelated, biochemical pathways and these disease-drivers need to be thoroughly interrogated in order to provide effective treatment options.

Dr. David de Graaf, president and CEO Selventa, remarked, “SysDx is a natural outgrowth of our successful 10-year heritage as a leader in systems biology and biomarker identification for pharma and biotech. Our ‘Big Data’ analytics and algorithms uniquely integrate, process, and analyze different molecular information from thousands of patients to identify biomarkers. This unique capability is the foundation for SysDx tests that will have stronger validation, higher reliability, and provide superior predictive and prognostic capabilities.”

Selventa is currently focusing its SysDx development in autoimmune diseases and cancer. These complex multifactorial diseases require more than genetic information alone to gain an effective diagnosis that can guide treatment. Selventa’s lead product will be Clarify-RA, a SysDx test that will be able to predict which patients suffering from rheumatoid arthritis (RA) will not respond to the standard of care antitumor necrosis factor (TNF) therapy. RA is a chronic, debilitating disease that affects an estimated 2 million people in the United States. It is also an expensive disease to treat, costing the healthcare system on average USD 20,000 per patient every year. In moderate to severe RA patients, only 40% of patients gain a clinically significant benefit from the anti-TNFs.

Related Links:

Selventa




Sekisui Diagnostics
DiagCor Bioscience
VIRCELL
comments powered by Disqus
Life Technologies

Channels

Clinical Chemistry

view channel
Image: The URiSCAN Super Plus reflectance meter (Photo courtesy of YD Diagnostics).

Semiquantitative Urine Dipstick Evaluated for Microalbuminuria Screening

The urine microalbumin test is used as a screening test for the diagnosis of renal complications in diseases, such as diabetic nephropathy, cardiovascular disease, and hypertension. A urine dipstick... Read more

Microbiology

view channel
Image: The adult free-living female Strongyloides stercoralis with a row of eggs within the body of the nematode (Photo courtesy of the CDC - Centers for Disease Control and Prevention).

Rapid Serological Assay Developed for Strongyloidiasis

Several imperfect methods exist for diagnosing strongyloidiasis and stool examination with microscopic identification of larvae considered the gold standard diagnostic procedure, showing good specificity... Read more

Pathology

view channel
Image: The BD Viper LT System for fully automated, integrated molecular testing on a table top analyzer (Photo courtesy of BD Diagnostics).

Modern Methods Accurately Detects Cervical Cancer

The newer Papanicolaou test (Pap tests) and human papilloma virus (HPV) screening more accurately identify precancerous cellular changes that potentially develop into cervical cancer. Compared to a... Read more

Lab Tech.

view channel
Image: RNAscope detects TP63 mRNA expression in human prostate tissue (Photo courtesy of Advanced Cell Diagnostics).

RNA Biomarker Assay Now Manufactured According to Strict ISO Regulatory Criteria

A line of diagnostic kits that measures RNA biomarkers with single-molecule sensitivity is now being manufactured under the stringent requirements of ISO 13485:2003 certification. Advanced Cell Diagnostics, Inc.... Read more

Industry News

view channel

Social Diagnostics Start-Up to Provide Simple, Affordable Tests Worldwide

The Royal Tropical Institute (KIT; Amsterdam, Netherlands) is establishing a nonprofit, social diagnostics company that develops and markets tests for the diagnosis of poverty-related diseases. Infectious diseases have a global impact; they take no account of national borders and influence the stability of societies... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.