Features | Partner Sites | Information | LinkXpress
Sign In
AB Sciex
FOCUS DIAGNOSTICS, INC.
RANDOX LABORATORIES

Genetic Susceptibility Loci Identified for Colorectal Tumors

By Labmedica International staff writers
Posted on 04 Mar 2013
The genetic loci associated with colorectal tumor formation have been identified and could elucidate the mechanisms of pathogenesis.

Over the past several years, genome-wide association studies (GWAS), which focus on common single-nucleotide polymorphisms (SNPs), have successfully discovered low-penetrance loci for colorectal cancer.

A genome-wide association study was conducted that included 14 studies, 12,696 cases of colorectal tumors (11,870 cancer, 826 adenoma), and 15,113 controls of European descent. Of 2.7 million genetic variants identified, the 10 most statistically significant, previously unreported findings were followed up in six studies; these included 3,056 colorectal tumor cases (2,098 cancers, 958 adenomas) and 6,658 controls of European and Asian descent. The study was led by scientists at Fred Hutchinson Cancer Research Center (Seattle, WA, USA).

The international team uncovered mutations in the following genes which were all genetic variants that previously had not been associated with colorectal cancer: nucleic acid-binding protein (NABP), a gene involved in DNA repair; laminin, gamma 1 (LAMC1), the second gene in the laminin gene family found to be associated with colorectal cancer; cyclin D2 (CCND2), a gene involved in cell-cycle control, which is a key control mechanism to prevent cancer development; and T-box 3 (TBX3), a gene transcription factor that targets a known colorectal cancer pathway.

Ulrike Peters, PhD, MPH, the senior author of the study said, "If a person carries one or two copies of any of these genetic variants, their risk of colorectal cancer is increased by 10% to 40% compared to a person who does not harbor such DNA genetic variants. These findings could potentially lead to new drug targets and, in combination with previously identified genetic and environmental risk factors, identify subgroups of the population that can benefit most from colorectal-cancer screening and could be targeted for early or more frequent endoscopy, a very effective screening tool for colorectal cancer." The study was published online on December 21, 2012, ahead of the April print issue of the journal Gastroenterology.

Related Links:
Fred Hutchinson Cancer Research Center



VIRCELL
DiagCor Bioscience
ADVANCED INSTRUMENTS
comments powered by Disqus
Life Technologies

Channels

Immunology

view channel
Image: The fluorescence-activated cell sorting FACSCanto II flow cytometer (Photo courtesy of BD Biosystems).

Flow Cytometry Detects Lymphoproliferative Disorders in Fluid Specimens

Immunophenotypic analysis of hematopoietic cell populations by flow cytometry has emerged as a useful ancillary study in the diagnostic evaluation of serous effusions and cerebrospinal fluids (CSFs).... Read more

Pathology

view channel
Image: Histopathology of increased endomysial connective tissue from a patient with Duchenne Muscular Dystrophy. Necrotic fibers arrowed (Photo courtesy of Washington University in St. Louis).

New Partnership Designed to Automate Dystrophin Measurement

A developer of innovative ribonucleic acid (RNA)-based therapeutics, Sarepta Therapeutics, Inc. ( Cambridge, MA, USA), and a leading tissue-based companion diagnostics firm, Flagship Biosciences LLC (Boulder,... Read more

Lab Tech.

view channel
Image: A technical breakthrough for DNA imaging has been achieved that should quicken diagnosis of diseases for which analysis of DNA from single-cells is critical, such as early stage cancers and various pre-natal conditions (Photo courtesy of McGill University and Génome Québec Innovation Center).

Breakthrough DNA Analysis Technology to Hasten Problem Diagnosis

Researchers have achieved a technical breakthrough that should result in speedier diagnosis of diseases for which analysis of DNA from single-cells is critical, such as early stage cancers and various... Read more

Industry News

view channel

Most IVD Sector Companies Look Outside the EU and USA for Growth

Kalorama Information (New York City, NY, USA) has now published the 9th edition of its biennial market research report “Worldwide Market for In Vitro Diagnostics,” revealing estimates from its survey of the in vitro diagnostics (IVD) industry – presenting the trends, technologies, customer needs, and major suppliers with... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.