Features | Partner Sites | Information | LinkXpress
Sign In
RANDOX LABORATORIES
PURITAN MEDICAL
FOCUS DIAGNOSTICS, INC.

Semiconductor-Based Nanopore Sequencing Platform Developed for Molecular Diagnostics

By Labmedica International staff writers
Posted on 24 Jan 2012
A startup company is developing a semiconductor-based nanopore-sequencing platform that will be used for molecular diagnostic applications.

Genia, the Mountain View (CA, USA)-based startup has an alpha version of its single-molecule platform in hand and is currently optimizing the biochemistry for a beta system.

Stefan Roever, CEO and founder of the company declined to provide a commercialization timeline for the system or details regarding expected read length or accuracy, but noted that he believes the platform will be able to sequence genomes at a cost "one order of magnitude less" than other single-molecule systems.

He described the system as a "single-molecule electrical detection sequencing platform," and said that the company expects it to be useful for targeted resequencing and molecular diagnostics that involve both human genomics and viral or bacterial DNA.

A number of other firms are developing nanopore sequencing systems, but Stephen Roever said that Genia's focus on the underlying chip platform sets it apart from competitors.

"We focused on operationalizing the nanopores," Stephen Roever said. "We essentially developed a way to create what are effectively lipid bilayer nanopore complexes, so the biological nanopore is a transmembrane protein that's suspended in a lipid bilayer."

The company has developed a way to "automatically set up whole arrays of [the nanopores] on the surface of a semiconductor chip and integrated circuit," ultimately making a "very complicated" process "massively scalable."

"We have a working platform and chip, and we have the basic building blocks on the biochemistry side. The next step is to take those and assemble them into a robust chemistry," said Mr. Roever. "That's where the focus is going to be and there's a significant amount of work still to be done there."

Related Links:

Genia



KARL HECHT GMBH & CO KG
CELLAVISION AB
77 ELEKTRONIKA

Channels

Microbiology

view channel
Image: The VIKIA Malaria Ag Pf/Pan rapid diagnostic test (Photo courtesy of IMACCESS).

Malaria Rapid Diagnostic Test Evaluated At Point-Of-Care

For over a decade, the development of malaria rapid diagnostic tests (RDTs) has enabled reliable biological diagnostic testing in all situations where previously only clinical diagnosis was available.... Read more

Industry News

view channel

Clinical Lab Automation Sector at USD 5.4 Billion and Growing

Lab automation systems sold to clinical laboratories reached USD 5.4 billion in sales in 2014. Shortage of personnel will further drive these purchases, as will a need for new systems, according to a new market research report on the status of lab automation in both clinical and drug-discovery lab segments.... Read more
 
Copyright © 2000-2015 Globetech Media. All rights reserved.