We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




Events

09 Apr 2024 - 12 Apr 2024
15 Apr 2024 - 17 Apr 2024
23 Apr 2024 - 26 Apr 2024

Markers Predicting Obesity Can Be Detected In Urine

By LabMedica International staff writers
Posted on 10 May 2015
Print article
Image: Proton (1H) nuclear magnetic resonance (NMR) spectroscopy apparatus (Photo courtesy of Imperial College London).
Image: Proton (1H) nuclear magnetic resonance (NMR) spectroscopy apparatus (Photo courtesy of Imperial College London).
The prevalence of obesity and being overweight is rising worldwide, and there is a need to understand the relationship of obesity to increased risk of death from heart disease, stroke, diabetes, and cancer.

Chemical markers have been identified in urine that are associated with body mass and this discovery may provide new insights into how obesity leads to disease as it is estimated that obesity-driven disease results in 3.4 million deaths per year worldwide.

An international team of scientists led by those at Imperial College London (UK) analyzed urine samples from over 2,000 volunteers in the US and UK. Metabolic profiling of urine samples collected over two 24-hour time periods three weeks apart showed reproducible patterns of metabolite excretion associated with adiposity. The team used 24-hour urinary metabolic profiling by proton (1H) nuclear magnetic resonance (NMR) spectroscopy and ion exchange chromatography.

Exploratory analysis of the urinary metabolome using 1H NMR spectroscopy (Bruker; Coventry, UK) of the 1,800 US samples identified 29 molecular species, clustered in interconnecting metabolic pathways that were significantly associated with body mass index (BMI); 25 of these species were also found in the 444 samples in the UK validation cohort.

The investigators found multiple associations between urinary metabolites and BMI including urinary glycoproteins and N-acetyl neuraminate (related to renal function), trimethylamine, dimethylamine, 4-cresyl sulfate, phenylacetylglutamine and 2-hydroxyisobutyrate (gut microbial co-metabolites), succinate and citrate (tricarboxylic acid cycle intermediates), ketoleucine and the ketoleucine/leucine ratio (linked to skeletal muscle mitochondria) and branched-chain amino acid metabolism), ethanolamine (skeletal muscle turnover), and 3-methylhistidine (skeletal muscle turnover and meat intake).

Jeremy K. Nicholson, PhD, a professor and senior author of the study, said, “Obesity has become a huge problem all over the world, threatening to overwhelm health services and drive life expectancy gains into reverse. Tackling it is an urgent priority and it requires us to have a much better understanding of how body fat and other aspects of biology are related. These findings provide possible starting points for new approaches to preventing and treating obesity and its associated diseases.” The study was published on April 29, 2015, in the journal Science Translational Medicine.

Related Links:

Imperial College London
Bruker 


Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Specimen Collection & Transport
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
Gold Member
ADAMTS-13 Protease Activity Test
ATS-13 Activity Assay

Print article

Channels

Molecular Diagnostics

view channel
Image: MOF materials efficiently enrich cfDNA and cfRNA in blood through simple operational process (Photo courtesy of Science China Press)

Blood Circulating Nucleic Acid Enrichment Technique Enables Non-Invasive Liver Cancer Diagnosis

The ability to diagnose diseases early can significantly enhance the effectiveness of clinical treatments and improve survival rates. One promising approach for non-invasive early diagnosis is the use... Read more

Hematology

view channel
Image: The low-cost portable device rapidly identifies chemotherapy patients at risk of sepsis (Photo courtesy of 52North Health)

POC Finger-Prick Blood Test Determines Risk of Neutropenic Sepsis in Patients Undergoing Chemotherapy

Neutropenia, a decrease in neutrophils (a type of white blood cell crucial for fighting infections), is a frequent side effect of certain cancer treatments. This condition elevates the risk of infections,... Read more

Pathology

view channel
Image: The OvaCis Rapid Test discriminates benign from malignant epithelial ovarian cysts (Photo courtesy of INEX)

Intra-Operative POC Device Distinguishes Between Benign and Malignant Ovarian Cysts within 15 Minutes

Ovarian cysts represent a significant health issue for women globally, with up to 10% experiencing this condition at some point in their lives. These cysts form when fluid collects within a thin membrane... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.