We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




Events

09 Apr 2024 - 12 Apr 2024
15 Apr 2024 - 17 Apr 2024
23 Apr 2024 - 26 Apr 2024

HDL Cholesterol Efflux Capacity a Better Predictor of Cardiovascular Disease Risk Than Measurement of HDL or HDL Cholesterol

By LabMedica International staff writers
Posted on 30 Nov 2014
Print article
A recent paper strengthened the hypothesis that HDL (high-density lipoprotein) function, rather than the absolute concentration of this lipoprotein, is the key factor linking HDL and cardiovascular disease (CVD).

The link between levels of HDL cholesterol and cardiovascular disease (CVD) is well established, but the mechanisms underlying this association had remained elusive. To gain a better understanding of this relationship, investigators at the University of Texas Southwestern Medical Center (Dallas, USA) measured HDL cholesterol level, HDL particle concentration, and cholesterol efflux capacity at in 2,924 adults free from cardiovascular disease who were participants in the Dallas Heart Study, a probability-based population sample. Over a median follow-up period of 9.4 years the investigators evaluated the participants for development of atherosclerotic cardiovascular disease, defined as a first nonfatal myocardial infarction, nonfatal stroke, or coronary revascularization or death from cardiovascular causes.

Results revealed that cholesterol efflux capacity (cholesterol efflux), which measures HDL cholesterol function, appeared to be a superior indicator of cardiovascular risk and a better target for therapeutic treatments than standard measurements of HDL. In a fully adjusted model that included traditional risk factors, HDL cholesterol level, and HDL particle concentration, there was a 67% reduction in cardiovascular risk in participants with the highest quarter of cholesterol efflux capacity versus those with the lowest quarter.

“HDL is very dynamic. It has many functions that are not fully captured by the measurement of static cholesterol levels,” said first author Dr. Rohatgi, assistant professor of internal medicine at the University of Texas Southwestern Medical Center. “The hypothesis has changed from an HDL-cholesterol hypothesis to an HDL-function hypothesis to better capture cardiovascular risk and provide a better target for therapy to reduce that risk. We drew on the strengths of the Dallas Heart Study to thoroughly investigate the relationship between HDL function and cardiovascular disease What we found was a strong, graded, protective relationship between cholesterol efflux and incidence of cardiovascular events among people who were free from heart disease at baseline testing.”

The study was published in the November 18, 2014, online edition of the New England Journal of Medicine.

Related Links:

University of Texas Southwestern Medical Center


Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
One Step HbA1c Measuring System
GREENCARE A1c
POCT Fluorescent Immunoassay Analyzer
FIA Go
Gold Member
ADAMTS-13 Protease Activity Test
ATS-13 Activity Assay

Print article

Channels

Molecular Diagnostics

view channel
Image: MOF materials efficiently enrich cfDNA and cfRNA in blood through simple operational process (Photo courtesy of Science China Press)

Blood Circulating Nucleic Acid Enrichment Technique Enables Non-Invasive Liver Cancer Diagnosis

The ability to diagnose diseases early can significantly enhance the effectiveness of clinical treatments and improve survival rates. One promising approach for non-invasive early diagnosis is the use... Read more

Hematology

view channel
Image: The low-cost portable device rapidly identifies chemotherapy patients at risk of sepsis (Photo courtesy of 52North Health)

POC Finger-Prick Blood Test Determines Risk of Neutropenic Sepsis in Patients Undergoing Chemotherapy

Neutropenia, a decrease in neutrophils (a type of white blood cell crucial for fighting infections), is a frequent side effect of certain cancer treatments. This condition elevates the risk of infections,... Read more

Pathology

view channel
Image: The OvaCis Rapid Test discriminates benign from malignant epithelial ovarian cysts (Photo courtesy of INEX)

Intra-Operative POC Device Distinguishes Between Benign and Malignant Ovarian Cysts within 15 Minutes

Ovarian cysts represent a significant health issue for women globally, with up to 10% experiencing this condition at some point in their lives. These cysts form when fluid collects within a thin membrane... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.