Features | Partner Sites | Information | LinkXpress
Sign In
AB Sciex
RANDOX LABORATORIES
Bio-Rad Diabetes Division

Dye Checks Heparin Levels in Blood

By Labmedica International staff writers
Posted on 26 Feb 2013
Scientists have developed a dye that provides a quick and accurate method of checking heparin levels in the blood. The modified dye, which has excellent sensing capacity for heparin, pinpoints the anticoagulant's level in human serum and has the potential to work more quickly than existing clinical methods for doing this.

Because the dye can rapidly detect heparin levels, the scientists have named it “Mallard Blue,” (the same shade as the livery of the A4 Pacific Mallard, which holds the world speed record for a steam locomotive).

Heparin is an important anticoagulant, which has a significant role in major surgery. The scientists in the department of chemistry at York University (Toronto, Canada) studied biological systems to discover how the dye would bind heparin even in highly competitive human serum.

In the laboratory, the scientists modified existing dyes, which previously could not bind with heparin successfully under these challenging conditions. The scientists in the department of chemistry at York used inspiration from biological systems to allow the dye to bind heparin even in the highly competitive human serum. The modified dye, which has excellent sensing capacity for heparin pinpoints the anticoagulant’s level in human serum and has the potential to work more quickly than existing clinical methods for doing this. The work was published in the online edition of February 13, 2013, Journal of the American Chemical Society.

The York scientists worked with a team led by Sabrina Pricl at the University of Trieste (Italy), who used high-level computer modeling to understand precisely how Mallard Blue binds to heparin so strongly.

The next stage in this work will involve the incorporation of this new dye into a device for simple bedside read-out of heparin levels in blood.

Related Links:

York University
University of Trieste



PURITAN MEDICAL
77 ELEKTRONIKA
DiagCor Bioscience
comments powered by Disqus
Life Technologies

Channels

Genetic Tests

view channel
Histopathology of colonic adenocarcinoma; the glands are enlarged and filled with necrotic debris (Photo courtesy of the University of Utah).

Promising Blood Biomarkers Isolated for Colorectal Cancer

The search for blood-borne biomarkers that could be used to screen for colorectal cancer (CRC) has uncovered two promising candidates that may one day lead to the development of a simple blood test.... Read more

Microbiology

view channel
Image: The causative parasite of Chagas disease Trypanosoma cruzi in a blood film (Photo courtesy of the CDC - US Centers for Disease Control and Prevention).

Undiagnosed Chagas Disease Emerging as Public Health Threat

Chagas disease or American trypanosomiasis is typically spread to people through the feces of blood-sucking triatomine bugs sometimes called kissing bugs because they feed on people's faces during the night.... Read more

Industry News

view channel

Oncology Companion Diagnostics Sector Grows to Over USD 1 Billion

The market for diagnostic test and pharmaceutical drug pairs for cancer treatment has grown significantly, according to the report “Companion Diagnostic Markets” from healthcare market research firm Kalorama Information (New York City, NY, USA). The global companion diagnostics (CDx) market is valued at about USD 1.... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.