Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
RANDOX LABORATORIES

Dye Checks Heparin Levels in Blood

By Labmedica International staff writers
Posted on 26 Feb 2013
Print article
Scientists have developed a dye that provides a quick and accurate method of checking heparin levels in the blood. The modified dye, which has excellent sensing capacity for heparin, pinpoints the anticoagulant's level in human serum and has the potential to work more quickly than existing clinical methods for doing this.

Because the dye can rapidly detect heparin levels, the scientists have named it “Mallard Blue,” (the same shade as the livery of the A4 Pacific Mallard, which holds the world speed record for a steam locomotive).

Heparin is an important anticoagulant, which has a significant role in major surgery. The scientists in the department of chemistry at York University (Toronto, Canada) studied biological systems to discover how the dye would bind heparin even in highly competitive human serum.

In the laboratory, the scientists modified existing dyes, which previously could not bind with heparin successfully under these challenging conditions. The scientists in the department of chemistry at York used inspiration from biological systems to allow the dye to bind heparin even in the highly competitive human serum. The modified dye, which has excellent sensing capacity for heparin pinpoints the anticoagulant’s level in human serum and has the potential to work more quickly than existing clinical methods for doing this. The work was published in the online edition of February 13, 2013, Journal of the American Chemical Society.

The York scientists worked with a team led by Sabrina Pricl at the University of Trieste (Italy), who used high-level computer modeling to understand precisely how Mallard Blue binds to heparin so strongly.

The next stage in this work will involve the incorporation of this new dye into a device for simple bedside read-out of heparin levels in blood.

Related Links:

York University
University of Trieste



Print article

Channels

Genetic Tests

view channel

Patterns of MicroRNA Expression Distinguish Patients with Asthma and Allergic Rhinitis

Subsets of circulating micro RNAs (miRNAs) are uniquely expressed in asthmatic patients and in patients with allergic rhinitis (AR) and have potential for use as noninvasive biomarkers to diagnose and characterize these diseases. MicroRNAs are a class of about 20 nucleotides-long RNA fragments that block gene expression... Read more

Lab Tech.

view channel
Image: The cobas IT 1000 connectivity system (Photo courtesy of Roche).

New Application Connects Point-of-Care Coordinators via Tablet or Smartphone

A new mobile application has been released that allows point-of-care coordinators (POCCs) and laboratory supervisors to control operations from any location. Modern-day laboratories face modern-day challenges.... Read more

Industry News

view channel

R-Biopharm and Merck Partner on Companion Diagnostics

R-Biopharm AG (Darmstadt, Germany) and Merck KGaA (Darmstadt, Germany) have entered into an agreement that constitutes their first collaboration, which will initially focus on developing and launching companion diagnostics. Companion diagnostics play a central role in personalized medicine by helping to find specific... Read more
Copyright © 2000-2016 Globetech Media. All rights reserved.