Features | Partner Sites | Information | LinkXpress
Sign In
RANDOX LABORATORIES
GLOBETECH PUBLISHING
FOCUS DIAGNOSTICS, INC.

Liquid Cystatin C Assay– a Good Indicator of GFR

By Labmedica International staff writers
Posted on 27 Dec 2011
A liquid ready-to-use cystatin C assay provides a good indicator of glomerular filtration rate (GRF). As a more sensitive maker of renal dysfunction, cystatin C offers several advantages over traditional creatinine assays.

Cystatin C is unaffected by nonrenal factors including muscle mass, weight, height, age, gender, diet and drugs. Therefore it is particularly useful in cases where creatinine measurement is not appropriate e.g., in individuals who are obese, malnourished, or who have liver disease.

The Randox (Crumlin, United Kingdom) cystatin C assay is based on an immunoturbidimetric method and is suitable for use on a wide range of chemistry analyzers. All reagents are supplied liquid ready to use for added convenience; furthermore, reagents are stable for 28 days at +10 °C onboard the analyzer, minimizing the possibility of reagent waste.

The assay has a wide measuring range of 0.4 to 10 mg/L allowing both normal and abnormal values to be measured accurately and reliably without the need for additional dilutions. Further benefits include precision (CVs under 5%) and limited interference from bilirubin, hemoglobin, triglycerides, and intralipids. A full range of supporting quality controls and calibrators are also available.

Cystatin C is sensitive to changes in the “creatinine blind” range enabling detection of early reductions in GFR and subsequent early treatment of kidney disease. Cystatin C has several other advantages over creatinine; the ability of cystatin C to detect even small changes in GFR makes it the ideal marker for dosing medication eliminated by the kidneys. Cystatin C is also the preferred marker for estimating GFR in infants, the elderly, diabetics, and those with reduced muscle mass.

Traditionally creatinine was the most widely used marker of GFR and kidney function but several recent studies have documented cystatin C as a far superior and sensitive marker. Cystatin C is produced at a constant rate throughout the body and is removed and broken down by the kidneys, levels will therefore remain steady if the kidneys are working efficiently and the GFR is normal.

The prevalence of chronic kidney disease continues to increase dramatically as does the burden on healthcare resources. The early detection of kidney disease is crucial in order to lower healthcare costs, avoid disease progression, and reduce the need for dialysis or transplantation.

Related Links:

Randox


VIRCELL
Sekisui Diagnostics
DiagCor Bioscience
comments powered by Disqus
Life Technologies

Channels

Immunology

view channel
Image: The fluorescence-activated cell sorting FACSCanto II flow cytometer (Photo courtesy of BD Biosystems).

Flow Cytometry Detects Lymphoproliferative Disorders in Fluid Specimens

Immunophenotypic analysis of hematopoietic cell populations by flow cytometry has emerged as a useful ancillary study in the diagnostic evaluation of serous effusions and cerebrospinal fluids (CSFs).... Read more

Lab Tech.

view channel
Image: A technical breakthrough for DNA imaging has been achieved that should quicken diagnosis of diseases for which analysis of DNA from single-cells is critical, such as early stage cancers and various pre-natal conditions (Photo courtesy of McGill University and Génome Québec Innovation Center).

Breakthrough DNA Analysis Technology to Hasten Problem Diagnosis

Researchers have achieved a technical breakthrough that should result in speedier diagnosis of diseases for which analysis of DNA from single-cells is critical, such as early stage cancers and various... Read more

Industry News

view channel

Most IVD Sector Companies Look Outside the EU and USA for Growth

Kalorama Information (New York City, NY, USA) has now published the 9th edition of its biennial market research report “Worldwide Market for In Vitro Diagnostics,” revealing estimates from its survey of the in vitro diagnostics (IVD) industry – presenting the trends, technologies, customer needs, and major suppliers with... Read more
 
Copyright © 2000-2014 Globetech Media. All rights reserved.